Postdoctoral Fellow

Mass General Brigham • Belmont, CA

1d • Onsite

About The Position

We are seeking a highly motivated Postdoctoral Fellow to join our research program focused on the role of regulatory T cells (Tregs) in improving outcomes in cell replacement therapy for neurodegenerative disease. The successful candidate will lead studies aimed at defining how Tregs modulate immune responses associated with transplantation and how they may enhance graft survival and function. The postdoctoral fellow will investigate the immunosuppressive activity of Tregs, including their capacity to regulate host inflammatory responses before and after transplantation. A major emphasis of the project will be to understand the mechanisms that influence Treg survival, persistence, and function post-transplantation. The fellow will also study approaches to mitigate the pro-inflammatory response associated with needle trauma, a key barrier to successful cell delivery and engraftment. In addition, the candidate will explore the biology of local brain-resident or tissue-localized Tregs and their role in limiting neuroinflammation within the transplant microenvironment. This work will integrate cellular immunology, transplantation biology, and neuroinflammation, with the goal of developing strategies that improve the safety and efficacy of regenerative therapies in the central nervous system. This position offers the opportunity to contribute to a growing area of investigation at the interface of immunology, neuroscience, and regenerative medicine, with strong potential for high-impact publications and translational relevance.

Requirements

• Strong background in immunology, neuroimmunology, stem cell biology, transplantation biology, or a related biomedical field
• Independent
• Scientifically rigorous
• Enthusiastic about working in an interdisciplinary and translational research environment

Nice To Haves

• Experience with T-cell biology
• Experience with flow cytometry
• Experience with in vitro immune assays
• Experience with animal models
• Experience with histology
• Experience with molecular or cellular techniques

Responsibilities

• Lead studies aimed at defining how Tregs modulate immune responses associated with transplantation and how they may enhance graft survival and function
• Investigate the immunosuppressive activity of Tregs, including their capacity to regulate host inflammatory responses before and after transplantation
• Understand the mechanisms that influence Treg survival, persistence, and function post-transplantation
• Study approaches to mitigate the pro-inflammatory response associated with needle trauma
• Explore the biology of local brain-resident or tissue-localized Tregs and their role in limiting neuroinflammation within the transplant microenvironment
• Evaluate the immunosuppressive properties of Tregs
• Determine Treg survival and persistence following transplantation
• Identify mechanisms to reduce the pro-inflammatory response associated with needle trauma during cell delivery
• Investigate the role of local Tregs in the brain and their contribution to the control of local inflammation within the transplant environment

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees