Postdoctoral Fellow-MSH-13570-007
About The Position
The post-doctoral fellow will have duties that will include basic and translational research projects in urologic oncology. The Kyprianou lab focuses on the investigation of novel therapeutic targeting in metastatic, castration-resistant prostate cancer and renal cancer towards overcoming advanced disease and in collaboration with Dr. Navneet Dogra’s lab are investigating the identification of novel liquid biopsies and biomarkers of therapeutic resistance (exosomes). The Kyprianou lab is NIH funded and is well established in the field of translational research. The candidate post-doc will use a wide array of techniques including bioinformatics, immunohistochemical analysis of tumor tissue, pre-clinical PDX models, transgenic mouse models, isolation of extracellular vesicles from serum, flow-cytometry and molecular biology techniques (including RT-PCR, confocal microscopy) to define the underlying mechanisms of emergence of metastatic therapeutically resistant tumors and identify extracellular vesicles (EVs) as biomarkers of tumor progression.
Requirements
- PhD or equivalent degree in a relevant scientific field.
- Experience in basic and translational research.
- Experience in urologic oncology research.
- Experience with therapeutic targeting in metastatic, castration-resistant prostate cancer and renal cancer.
- Experience with liquid biopsies and biomarkers of therapeutic resistance (exosomes).
- Proficiency in bioinformatics.
- Experience with immunohistochemical analysis of tumor tissue.
- Experience with pre-clinical PDX models.
- Experience with transgenic mouse models.
- Experience with isolation of extracellular vesicles from serum.
- Experience with flow-cytometry.
- Experience with molecular biology techniques (including RT-PCR, confocal microscopy).
- Ability to define underlying mechanisms of tumor progression and resistance.
Responsibilities
- Conduct basic and translational research projects in urologic oncology.
- Investigate novel therapeutic targeting in metastatic, castration-resistant prostate cancer and renal cancer.
- Identify novel liquid biopsies and biomarkers of therapeutic resistance (exosomes).
- Use bioinformatics, immunohistochemical analysis of tumor tissue, pre-clinical PDX models, and transgenic mouse models.
- Isolate extracellular vesicles from serum.
- Utilize flow-cytometry and molecular biology techniques (including RT-PCR, confocal microscopy).
- Define the underlying mechanisms of emergence of metastatic therapeutically resistant tumors.
- Identify extracellular vesicles (EVs) as biomarkers of tumor progression.
Benefits
- Commitment to fostering an environment where everyone can contribute to excellence.
- Shared dedication to delivering outstanding patient care.
- Opportunity to be part of an unparalleled legacy of achievement, education, and innovation.
- Encouragement to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.
- Leaders committed to fostering a workplace where all employees feel valued, respected, and empowered to grow.
- Environment where collaboration, fairness, and continuous learning drive positive change.
- Supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
