Postdoctoral Fellow – Next-Gen Sequencing Systems, Research & Early Development

Roche • Santa Clara, CA

1d • $100,000 - $106,000 • Onsite

About The Position

At Roche, we are developing the next-generation of sequencing systems. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are also broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing workflows. We are seeking a talented and highly motivated Postdoctoral Fellow with a proven track record of excellence in developing novel technology for biological applications. Joining our Systems Technology Group, you will play a major role in the Research and Early Development of new technology, devices, and instruments associated with our next-generation DNA sequencing and molecular diagnostic platforms. At the heart of these instruments are highly integrated microfluidic systems capable of automating intricate workflows and handling complex biochemistry. To gear up for these ambitious goals, your near-term focus will involve deep, hands-on training with our foundational efforts. You will assist with current projects to master our chemistry, materials, and methods, gaining critical expertise in how we design, fabricate, bond, simulate, operate, characterize, and troubleshoot complex systems and processes. This is a hands-on, interdisciplinary role designed to bridge the gap between biochemical applications and cutting-edge instrumentation. Collaborating closely with a small, agile team and the broader organization, you will solve challenging problems, invent new technology, and ultimately advance the state-of-the-art in DNA sequencing systems.

Requirements

• Ph.D. in Bioengineering or a closely related discipline with a thesis focused on solving a molecular biology problem with clever engineering.
• Solid understanding of physics, engineering, chemistry, molecular biology and sequencing fundamentals.
• Demonstrated experience with advanced microfabrication techniques (lithography, thin-film deposition, wet/dry etching, and thermal fusion bonding processes).
• Demonstrated success porting complex biochemical assays or workflows onto novel fluidic systems and optimizing performance using a systematic approach.
• Solid publication record, including at least one first-authored and peer-reviewed publication in a top-tier journal.
• Demonstrated experience with Python scripting for instrument hardware control.
• Demonstrated interest regarding market trends; you have a foundational knowledge of our peers work.

Nice To Haves

• Experience designing and testing microfluidic systems with active components and integrated sensors.
• Experience building, operating, and troubleshooting fixtures or breadboards with fluidic, pneumatic, thermal, and optical subsystems.
• Proficient in operating and interpreting data from analytical instruments (e.g., qPCR, dPCR, Bioanalyzer/TapeStation, Qubit, NanoDrop).
• High-level perspective with the ability to see the bigger picture and a desire to challenge the status quo.
• Team player, strong problem-solving, judgment and decision-making skills; known for your high level of attention to detail at scale in a fast-paced environment.
• Strong communication skills including the ability to communicate with all levels within the organization; hands-on, self-directed, organized, conscientious.
• Strong time management and organizational skills in a dynamic, continually changing environment; ability to communicate effectively (both orally and in writing) with management, peers and individuals.
• Ability to work effectively, exhibit a professional manner and establish constructive working relationships.

Responsibilities

• Design, fabricate, and assemble custom devices, fixtures, and breadboards using various rapid prototyping tools, including custom equipment.
• Develop and implement microfabrication processes, including photolithography, etching, drilling, bonding, and dicing—and utilize precision metrology instruments to characterize components and evaluate manufacturing methodologies.
• Create and characterize new materials and bonding methodologies.
• Test, characterize, and troubleshoot complex fluidic systems and devices.
• Develop and optimize workflows on these systems while collecting, analyzing, and interpreting data to drive technical progress.
• Generate comprehensive test plans, protocols, technical reports and invention disclosures to document findings and methodology.
• Select, procure, install, validate, operate, repair, and maintain lab/fab equipment and custom instrumentation.

Benefits

• Competitive salaries
• Fully funded research expenses
• Mentorship and support
• Access to world class seminars and networking opportunities with leading scientists
• Relocation benefits are not provided for this role.
• Roche Benefits

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree