Postdoctoral Fellow, Microtissue Signaling Dynamics

Biohub • Chicago, IL

22h • Hybrid

About The Position

Biohub is a large-scale initiative integrating frontier AI models, massive compute, and experimental capabilities to accelerate scientific discovery and cure disease. The Microtissue Signaling Dynamics team studies cellular communication in tissues during disease and immune responses. They use multimodal data from tissues and advanced microfluidic platforms to understand disease progression and treatment responses. By integrating experimental data with computational approaches like network modeling, information theory, and machine learning, the team aims to identify key indicators of disease state and develop better therapeutic strategies for autoimmune diseases and cancer. This role offers an opportunity to work on developing innovative devices for culturing and testing various tissues, contributing to technology development, bioengineering, and disease-focused discovery in a well-funded, collaborative environment. Postdoctoral Fellows will be part of interdisciplinary teams applying and developing microfluidic devices to simulate inflammatory disease mechanisms, with a focus on skin and/or gut tissue models. The role requires designing and executing quantitative experiments using imaging, fluid handling, automation, or profiling technologies to analyze cellular heterogeneity, immune cell states, and tissue-level responses. Projects are aligned with the Biohub's mission to uncover fundamental disease mechanisms and develop transformative measurement technologies. Biohub Chicago is committed to training scientists for impactful careers.

Requirements

• Programming including Matlab, python, and/or C++.
• Cleanroom/Soft lithography experience (Laser writer, spin-coating, DRIE, etc).
• Multilayer microfluidic device fabrication.
• Experience with handling mammalian cell or tissues.
• Experience with advanced microscopy (confocal and/or light-sheet microscopy).
• Image analysis.

Responsibilities

• Develop microfluidic platforms for skin and/or gut tissue.
• Develop the code to operate various components in the integrated system including fluidic handling (robotic pipette), other mechanical and electrical parts, and imaging.
• Perform the experiments to simulate various disease scenarios.
• Analyze the data: sequential volumetric images and cytokines or other protein profiles in the biofluid in collaboration with other teams in Biohub.
• Actively collaborate with other teams in the Biohub.

Benefits

• Generous employer match on employee 401(k) contributions.
• Paid time off to volunteer at an organization of your choice.
• Funding for select family-forming benefits.
• Relocation support for employees who need assistance moving.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: No Education Listed