Postdoctoral Associate, Sur Lab

MIT•Cambridge, MA

2d•Onsite

About The Position

The Postdoctoral Associate will join the Sur Lab at the Picower Institute for Learning and Memory. The lab's goal is to discover fundamental mechanisms of brain wiring and processing and how they go awry in disorders of brain development. This role is responsible for conducting research to study the molecular mechanisms of Rett Syndrome using human stem cells and combined molecular and microscopy technologies to study the early mechanisms of Rett Syndrome and other neurodevelopmental disorders in vitro.

Requirements

PhD in neuroscience, biological science, or related field
Ability with iPSC/organoid culture, mouse models, microscopy (multiphoton imaging preferred), histology and immunohistochemistry as well as molecular techniques
Demonstrated expertise in human iPSC culture
Superior oral and written communication skills
Ability to analyze data and present it in a format suitable for publication

Nice To Haves

Research experience studying disease mechanisms and molecular signaling pathway in a neurological condition
Computational expertise: experience analyzing calcium/voltage imaging data (Python, MATLAB) or transcriptomic data (R, Python, Seurat, or similar)
Genomic engineering: proficiency with CRISPR-based genome editing and isogenic model generation
Synthetic biology/molecular cloning: familiarity with molecular biology techniques for construct the plasmid and validation

Responsibilities

Performing human pluripotent stem cell maintenance and differentiation into brain organoids and 2D cultures
Identifying and validating molecular and cellular targets
Working independently to generate and analyze data
Working with collaborating research groups and core facilities
Planning and performing experiments
Collecting and analyzing data using quantitative techniques

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