Postdoctoral Associate | Laboratory of Genetically Encoded Small Molecules

Rockefeller University • New York, NY

51d • Onsite

About The Position

Researchers in the Laboratory of Genetically Encoded Small Molecules are working on projects related to the human microbiome, bacterial small molecules, and host-microbial interactions. The lab's research is focused on identifying bacterial genes, pathways, and molecules that influence host-cellular functions and developing these host-microbial interactions into novel treatments for human disease. To this end, we focus on three major areas of research: 1) high throughput screening of bacterial metabolites and genes to identify effector functions, 2) mouse models of inflammatory and metabolic diseases, and 3) in vivo validation of bacterial metabolites and genes in human cohorts. The Postdoctoral Associate will use methods from molecular biology, organic chemistry, and microbiology to access bioactive natural products and their respective biosynthetic gene clusters from the soil. Will be responsible for using a range of techniques, including molecular biology, tissue culture, animal work (mouse), and chemistry.

Requirements

• PhD in chemistry, biochemistry, microbiology, biology, or a related field
• Ability to independently conduct untargeted metabolomics studies and/or phylogenetic analyses of microbial communities in microbiome samples.
• Strong organization skills, attention to detail, and ability to maintain accurate records
• Excellent communication skills and the ability to work both independently and as part of a collaborative team in a fast-paced research environment

Nice To Haves

• Experience in multi-step natural product synthesis, medicinal chemistry, small molecule library development, compound characterization, and/or structure activity relationship optimization
• Experience in preparative and analytical chromatography and structural analysis of organic molecules
• Experience in peptide synthesis
• Experience with metabolite discovery and characterization

Responsibilities

• Design and execute independent and collaborative research projects.
• Maintain strong organizational practices, attention to detail, and accurate research
• Communicate effectively and work both independently and collaboratively
• Engage in scientific writing and dissemination activities, including opportunities to lead first-authored manuscripts and contribute to collaborative publications and literature reviews
• Perform related duties & responsibilities as assigned/requested

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree