Post-Doctoral Scientist– Molecular Pharmacology

Lilly • Indianapolis, IN

31d • $58,000 - $123,200 • Onsite

About The Position

The Molecular Pharmacology group in Lilly Small Molecule Discovery (LSMD) and Cardiometabolic research unit (CMR) is seeking an ambitious post-doctoral scientist with strong research and communication skills to contribute to highly visible research projects. Your work will focus on establishing and applying assays to evaluate mitochondrial uncouplers in a context- and system-dependent manner, and on screening for novel small molecule uncouplers with potential to treat metabolic disease. In this role, you will:
Develop and validate assays to identify small molecule uncouplers.
Characterize in vitro mitochondrial uncoupling activity across cell types, tissues, and disease-relevant systems.
Work with and be mentored by experts in bioenergetics, molecular pharmacology, and metabolic disease biology.
Design and execute small molecule screens to identify novel mitochondrial uncouplers, and characterize their mechanism of action, potency, selectivity, and safety margin using cutting edge industry technology and resources.
Identify areas of key need across clinical development and champion creative solutions to address those needs. Maintain external awareness and learning to benefit the organization.
Present findings at conferences and publish in high quality peer-reviewed journals.

Requirements

• Ph.D. in Molecular Biology, Biochemistry, Cell Biology, Pharmacology, or a related field
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization and visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.
• Demonstrated hands-on experience with molecular biology techniques, including CRISPR/Cas9 gene editing (e.g., guide RNA design, generation of knockout/knock-in cell lines, validation of edits)
• Proficiency in RT-PCR/qPCR techniques for gene expression analysis
• Strong scientific communication skills and a record of peer-reviewed publication.

Nice To Haves

• Experience with plate-based assay technologies such as TR-FRET, BRET, AlphaLISA, or similar high-throughput biochemical/cellular assay platforms preferred
• Familiarity with cellular target engagement assays (e.g., CETSA, NanoBRET target engagement, or similar approaches) preferred
• Experience with cell-based imaging techniques, including high-content/high-throughput imaging, fluorescence microscopy, or confocal imaging, for applications such as target engagement, phenotypic profiling, or trafficking studies
• Experience with proteomics and/or chemical biology approaches (e.g., mass spectrometry-based proteomics, activity-based protein profiling, chemical probe development) is a plus

Responsibilities

• Develop and validate assays to identify small molecule uncouplers.
• Characterize in vitro mitochondrial uncoupling activity across cell types, tissues, and disease-relevant systems.
• Work with and be mentored by experts in bioenergetics, molecular pharmacology, and metabolic disease biology.
• Design and execute small molecule screens to identify novel mitochondrial uncouplers, and characterize their mechanism of action, potency, selectivity, and safety margin using cutting edge industry technology and resources.
• Identify areas of key need across clinical development and champion creative solutions to address those needs.
• Maintain external awareness and learning to benefit the organization.
• Present findings at conferences and publish in high quality peer-reviewed journals.

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree