Post Doctoral Scientist - Molecular Pharmacology

Lilly • Indianapolis, IN

2d • $58,000 - $123,200 • Onsite

About The Position

Are you looking to make an impact in drug discovery at the frontier of G-protein coupled receptor (GPCR) science? We are seeking an ambitious post-doctoral scientist with strong research and communication skills to contribute to a high-visibility research program in quantitative GPCR pharmacology. GPCRs represent the single largest gene family encoding targets for approved drugs, including several of Lilly’s most impactful medicines. Despite transformative advances in molecular pharmacology and structural biology, the theoretical frameworks used to describe GPCR drug action remain incomplete. This project will address that gap directly — developing new mechanistic models to explain binding mechanisms that existing pharmacological theory cannot adequately describe. In this role, you will conduct innovative molecular pharmacology studies to characterize the mechanisms of action of GPCR ligands across multiple receptor systems of therapeutic relevance. You will work with and be mentored by industry-leading molecular pharmacologists, structural biologists, computational scientists, and medicinal chemists. You will also present findings at internal and external scientific meetings and publish extensively in high-quality peer-reviewed journals. This position provides the opportunity to conduct cutting-edge research with world-class industry resources and technology, while gaining direct experience of the drug discovery process. The candidate will develop deep expertise in quantitative GPCR pharmacology at the intersection of molecular pharmacology, structural biology, and disease biology.

Requirements

• PhD in pharmacology, biochemistry, biophysics, molecular biology, or a closely related life science discipline
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization and visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

Nice To Haves

• Training or background in membrane receptor biology, receptor pharmacology, signal transduction, or quantitative pharmacology would be advantageous
• Self-directed and highly motivated, with a commitment to pursuing both technical excellence and publication goals
• Excellent communicator (oral and written) with a strong or developing publication record
• Proficient in data analysis, graphing, and scientific reporting (e.g., GraphPad Prism, Python, Excel, PyMOL, MOE)
• Experience with ligand binding techniques (competition, saturation, kinetic assays) in live cell or membrane formats
• Experience with cell-based GPCR signaling assays, including cAMP, IP1, β-arrestin recruitment, intracellular calcium measurement, or phosphoprotein measurement
• Familiarity with quantitative pharmacological modelling or kinetic simulation approaches
• Experience with mammalian cell culture and standard molecular biology techniques
• Understanding or practical experience of modern structural and computational biology approaches
• Interest in the mechanistic and theoretical foundations of receptor pharmacology

Responsibilities

• Conduct innovative molecular pharmacology studies to characterize the mechanisms of action of GPCR ligands across multiple receptor systems of therapeutic relevance.
• Work with and be mentored by industry-leading molecular pharmacologists, structural biologists, computational scientists, and medicinal chemists.
• Present findings at internal and external scientific meetings and publish extensively in high-quality peer-reviewed journals.

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• eligibility for medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree