Post-Doctoral Scientist- Immunology Discovery

Lilly • San Diego, CA

5d • $58,000 - $123,200 • Onsite

About The Position

Eli Lilly and Company's Immunology organization is seeking a highly motivated Postdoctoral Research Fellow to lead a mechanistic research program comparing two clinically important T cell–redirecting immunotherapy platforms: bispecific T cell engagers (TCEs) and chimeric antigen receptor (CAR) T cell therapies, including transient mRNA-encoded CAR approaches. This is a unique opportunity to conduct hypothesis-driven, publication-caliber research at the interface of basic immunology and translational drug discovery, embedded within an active, industry-leading immunology discovery team. The postdoctoral fellow will design and execute a systematic, multi-aim research program using established internal reagents, cell lines, and assay platforms, with the goal of generating valuable mechanistic insights.

Requirements

• Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field (completed or near completion).
• Strong foundational knowledge of T cell biology
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization and visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

Nice To Haves

• Direct research experience with T cell engagers (TCEs) and/or CAR T cell platforms, including cytotoxicity assays and mechanistic characterization.
• Hands-on experience with primary human immune cell isolation and culture, multiparameter flow cytometry, and standard immunoassay techniques.
• Experience with multiplex cytokine profiling (e.g., MSD), transcriptional profiling (e.g., NanoString or scRNA-seq), and/or lipid nanoparticle–mediated mRNA delivery.
• Familiarity with regulatory T cell biology and immune subset dissection techniques.
• Excellent communicator (oral and written) with presentation experience, along with a strong publication record.
• Proficient in data analysis and reporting
• Previously experienced with multidimensional flow cytometry.
• Experience with scRNA-seq data acquisition and analysis

Responsibilities

• Support immunology research project advancing understanding of T Cell biology in the context of T Cell Engagers and CAR T Cell Therapies
• Work in close collaboration with immunology research, in vivo pharmacology and bioinformatics groups
• Perform phenotypic and functional characterization of T cells using: Primary human T and B cell isolation and co-culture, Multiparameter flow cytometry, Multiplex cytokine profiling (MSD), Transcriptional profiling (NanoString; potential single-cell RNA sequencing)

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree