Post-Doctoral Scientist – Advanced Resin Characterization for TIDES Manufacturing

Eli Lilly and Company • Indianapolis, IN

2d • $58,000 - $123,200 • Onsite

About The Position

Synthetic Molecule Design and Development (SMDD) is involved in key activities for the development of synthetic active pharmaceutical ingredients from pre-clinical phases through commercialization of drug substances and drug products. Our scientists and engineers develop key technical and business solutions across the portfolio using their deep technical expertise to accelerate testing of the clinical hypothesis and overall drug development. SMDD delivers on these responsibilities by recognizing diverse talent and cultures are necessary to bring the next generation of life changing medicines to patients. You will be part of a diverse team of scientists.

Requirements

• PhD in Chemistry, Analytical Chemistry, or Chemical Engineering.
• Familiarity with advanced characterization techniques for particle size and active sites distribution quantification, pore size, and volume measurements.
• Prior experience in heterogeneous reaction system characterization, knowledge of intra particle mass diffusion, and its competitive effects on reaction rate.
• Strong technical skills in synthetic organic chemistry with experience as a hands-on technical contributor in a laboratory environment.

Nice To Haves

• Familiarity with reversed phase chromatography, ion exchange chromatography, size exclusion chromatography, chiral chromatography.
• Prior experience of solid phase and/or liquid phase synthetic peptide and oligonucleotide process is preferred but not required.
• Ability to learn and apply technical knowledge to meet changing project needs.
• Flexibility and ability to prioritize work to meet interpersonal and scientific goals.
• Strong verbal and written communication skills and ability to collaborate in a team environment.
• Ability to balance multiple activities, prioritize and handle ambiguity.
• Breadth in multiple resin characterization techniques, reaction engineering knowledge and peptide synthesis techniques.
• Strong technical problem-solving ability and have an internal motivation to work independently and achieve efficient, quality results in a fast-paced environment.

Responsibilities

• Develop advanced analytical techniques characterizing resin support for solid phase peptide and oligonucleotide synthesis.
• Quantify internal resin mass diffusion effects on solid phase peptide and oligonucleotide synthesis reaction efficiency.
• Show proficiency in multiple modes of peptide and oligonucleotide synthesis including solid phase and liquid phase synthesis.
• Have familiarity with chromatography, mass spectrometry, optical spectroscopy, and peptide automation.
• Present research findings at conferences and publish in high quality peer-reviewed journals.
• Work collaboratively with one of best peptide research groups in the pharmaceutical Industry.
• Identify and develop advanced resin characterization techniques for peptide synthesis.
• Conduct and perform chemical reactions in the laboratory and collect experimental data to support developing sustainable synthetic peptide projects.
• Identify and exploit new scientific concepts, strong problem-solving skills, and be self-motivated to contribute across multiple projects.
• Collaborate with cross-functional teams to translate innovative ideas into designs, prototypes, and project implementations.
• Strong written and verbal communication to speak to both technical and business-related implications of your work.
• Provide regular updates on project status, milestones, challenges, and next steps to the supervisor and leadership.

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Career Level: Entry Level
• Education Level: Ph.D. or professional degree