Post-Doc Research Associate

UNC-Chapel Hill • Chapel Hill, NC

2d

About The Position

The purpose of the post-doctoral position is to conduct research in the Armistead Laboratory, which investigates T-cell responses to cancer. The post-doc will engage in an already started project investigating T-cell responses to cancer and viral antigens presented by HLA -E. The Armistead Lab and collaborators have identified a T-cell receptor that targets virus-derived peptide epitopes presented by HLA -E. HLA -E is overexpressed in many cancers, particularly virally driven cancers, and the research to be conducted by this post-doc will be to further characterize the magnitude and specicity of this T-cell response in both cancer cell lines and normal cells. In addition the post-doc will work to identify additional cancer-associated or virus-derived peptides that are presented by HLA -E.

Requirements

• PhD in a relevant scientific field (Microbiology, Immunology, Biomedical Engineering, Cell Biology)
• Experience in mammalian tissue culture methods
• Experience in retroviral gene transduction in human cell lines and human primary cells
• Molecular biology experience and significant experience in plasmid and vector design
• Experience in flow cytometry and cell sorting
• Experience in T-cell functional assessment and understanding of HLA -restriction
• Experience in HLA /peptide elution and peptide identification by mass spectrometry

Nice To Haves

• PhD in related field.

Responsibilities

• Conduct research in the Armistead Laboratory investigating T-cell responses to cancer.
• Engage in an ongoing project investigating T-cell responses to cancer and viral antigens presented by HLA -E.
• Further characterize the magnitude and specificity of the T-cell response in cancer cell lines and normal cells.
• Identify additional cancer-associated or virus-derived peptides presented by HLA -E.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree