Post Doc Res Assoc

The University of Utah • Salt Lake, UT

3d

About The Position

The Jurynec Lab (Department of Orthopaedics, www.juryneclab.org) is looking for a highly motivated and independent Post Doctoral Research Fellow to be part of a multidisciplinary team studying the genetics of osteoarthritis. The lab uses human genetics, bioinformatics, molecular biology, and animal models to understand the factors that contribute to the onset and progression of osteoarthritis. The Jurynec Lab has identified over 100 candidate gene variants that segregate with osteoarthritis in large pedigrees. We are analyzing candidate gene functions in zebrafish and generating mice carrying human disease alleles to understand the contribution of these genes to the osteoarthritis phenotype. Analyses include CRISPR /Cas9 genome editing in mice and zebrafish, scRNA-seq, spatial profiling, WES / WGS , and tissue culture. The candidate should be prepared to analyze gene function in vivo and perform genetic and chemical screens in vitro to identify potential therapeutics. The lab is funded by the NIH and foundation grants. The applicant will be responsible for leading independent projects under the guidance of the PI. These studies include performing experiments with zebrafish, mice, and tissue culture. The applicant will also be responsible for the maintenance and breeding of zebrafish and mice.

Requirements

• Candidates should have a PhD, MD, or MD/PhD (or equivalent) degree or should be close to obtaining their doctoral or medical degree.
• A working knowledge of advanced molecular biology, cell biology, and genomics techniques as well as the ability to make statistical calculations, analyze results, prepare reports and perform specialized tests also required.
• Two letters of recommendation are required.
• The applicant must demonstrate proficiency in molecular biology techniques, including, but not limited to PCR , DNA cloning, and working with RNA .
• Experience with animals is required.
• OSHA training and certification in animal care and use or the willingness to complete the certification will be required.
• IRB CITI Course in the Protection of Human Research subjects certificate obtained within two months of hire and demonstrated human relations and effective communication skills are also required.
• Some departments may require IATA DGR training within two months.
• Applicants must demonstrate the potential ability to perform the essential functions of the job as outlined in the position description.

Nice To Haves

• Experience with tissue culture is preferred, but not required.

Responsibilities

• Performs and directs specialized and complex lab tests, experiments and surgical procedures for studies.
• Assists the Principal Investigator in the design, implementation and performance of new protocols and procedures as well as the modification of existing techniques.
• Reviews scientific journals, abstracts and other literature for information concerning experimental procedures.
• Makes advanced statistical calculations, analyzes data and prepares reports summarizing research results.
• Operates complex and highly specialized laboratory and surgical instruments and equipment. Instructs others in their use.
• Maintains a log of supplies used in procedures.
• May supervise, train and review the work of laboratory personnel.
• May prepare equipment and rooms for studies.
• May assist with preparing budgets.

What This Job Offers

• Job Type: Full-time
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees