PKD Preclinical Core Professional or Lead

University of Colorado•Aurora, CO

27d•Onsite

About The Position

Dr. Katharina Hopp directs the basic research Polycystic Kidney Disease (PKD) program at CU Anschutz. As part of the program, she directs the PKD preclinical core which utilizes different rodent models of PKD to screen compounds for their efficacy to slow kidney cyst growth and delay end stage kidney failure. Beyond being director of this core, the Hopp laboratory researches the role of immune cells and immunometabolism in PKD utilizing both basic and translational research approaches that include in vitro, ex vivo, and in vivo methodologies. She believes that these studies will provide novel insights into the pathomechanisms of disease/disease heterogeneity and give rise to new therapeutic approaches. This position is for the PKD Preclinical Core Manager. Most of the work will focus on duties associated with preclinical trail execution using the available rodent models of PKD. A minor part of the work will include lab management and experimental support of Dr. Hopp’s laboratory research efforts.

Requirements

Senior Level: Bachelor’s degree in biology, molecular or cellular biology, chemistry, genetics or closely related fields.
An advanced degree (Masters or PhD) may be substituted for experience on a year for year basis if the degree is in a field of study directly related to the work assignment.
Two (2) years professional level research experience in an experimental or wet laboratory with hands on experience using rodent models for basic/translational studies.
Principal Professional level: Bachelor’s degree in biology, molecular or cellular biology, chemistry, genetics or closely related fields.
An advanced degree (Masters or PhD) may be substituted for experience on a year for year basis if the degree is in a field of study directly related to the work assignment.
Three (3) years professional level research experience in an experimental or wet laboratory with hands on experience using rodent models for basic/translational studies.
Applicants must be legally authorized to work in the United States without requiring sponsorship. We are unable to provide work visa sponsorship or employment authorization for this position now or in the future.
Advanced knowledge of basic laboratory techniques including rodent breeding, handling, and dissections as well as standard safety procedures and techniques (Senior level)
Expert knowledge of laboratory techniques including rodent breeding, handling, and dissections as well as standard safety procedures and techniques (Principal level)
Advanced ability to organize, manage, analyze, and present research data/findings and solve complex problems (Senior level)
Expert ability to organize, manage, analyze, and present research data/findings and solve complex problems (Principal level)
Ability to communicate effectively, both in writing and orally
Ability to establish and maintain effective working relationships with employees at all levels throughout the institution
Outstanding customer service skills
Knowledge of basic human anatomy, physiology medical terminology
Ability to interpret and master complex research protocol information
Expert level knowledge of either (1) preclinical trail execution and using murine models, (2) murine models of polycystic kidney disease, (3) studies of renal pathophysiology using murine models.

Nice To Haves

Master’s degree in biology, molecular biology, chemistry, genetics or closely related fields
Senior Professional level: Two (2) years of experience in an experimental or wet laboratory with hands on experience using rodent models for translational preclinical studies of human disease pathophysiology.
Principal Professional level: Three (3) years of experience in an experimental or wet laboratory with hand on experience using rodent models for translational preclinical studies of human disease pathophysiology.

Responsibilities

Manage and maintain the animal colony of the PKD preclinical core.
Perform preclinical trail execution including study group assignments, drug administration, in vivo disease testing (e.g., kidney function, ultrasounds, MRI), animal dissections, tissue embedding, and histological disease assessments.
Gather, organize, and analyze outcome date obtained from preclinical trails.