Oligonucleotide Process Technology Co-op (Spring 2027)
About The Position
Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease. Wave Life Sciences, an oligonucleotide therapeutics company, seeks a highly motivated co-op student to join its team of scientists in Lexington, Massachusetts. The co-op student will gain exposure to the areas of oligonucleotide synthesis, chromatographic purification, tangential flow filtration (TFF) and analysis. Co-ops will be trained in a variety of laboratory techniques and instrumentation, making this an excellent learning opportunity. This is an ideal position for any student, including those looking for their first co-op, with strong organizational skills and attention to detail who thrive in a team-oriented, fast-paced, and cross-disciplinary biotech environment. Organic chemistry or Biochemistry laboratory experience is preferred.
Requirements
- Strict adherence to lab safety protocols including PPEs.
- Effective communication skills and ability to present experimental results at group meetings
Nice To Haves
- Organic chemistry or Biochemistry laboratory experience
Responsibilities
- Reagent preparation & column packing for Oligo synthesis
- Buffer preparation, cleaning and sanitization of equipment used to manufacture oligonucleotides
- Purification of oligonucleotides
- Oligonucleotide synthesis preparation and handling of amidites
- Oligo quantitation using spectrophotometers
- Tangential Flow Filtration of purified oligos
- Operation of automated oligonucleotide synthesizers, purifiers, tangential flow filtration (TFF) systems and Lyophilizers
- Analysis of oligonucleotide samples by UPLC and LC-MS
- Using excel spreadsheets for data processing, analysis, and interpretation
- Documentation of lab experiments in an electronic notebook (ELN)
- Batch record review
- Inventory maintenance
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What This Job Offers
Career Level
Intern
Education Level
No Education Listed
