Medical Director

Flatiron Health

22d • Remote

About The Position

Flatiron Health is seeking a data- and technology-oriented clinician with oncology expertise and an interest in using real-world evidence to advance cancer care. The Medical Director will join the Global Research Oncology team, which works across the US, UK, Germany, and Japan. In collaboration with clinicians, data scientists, epidemiologists, software engineers, product managers, account directors, and clinical data specialists, this role helps develop, commercialize, and deliver oncology research data and services, including those leveraging artificial intelligence. The position serves as a core medical resource focused particularly on precision medicine and cancer genomics, helping biopharma clients apply clinical and molecular use cases across the R&D lifecycle, from early discovery through post-market development.

The role provides clinical and precision-medicine expertise for custom data requests, supports translational research and discovery, and helps clients apply real-world data to clinical development and trial design. It also contributes to pre-sales scoping, cross-functional project delivery, internal training and documentation, and research projects that may include presenting at scientific conferences. The level may be Associate Medical Director or Medical Director depending on experience and prior ownership in precision medicine.

This is a remote position. Employees may choose their work location and align their working hours with their team. Flatiron describes its benefits as supporting employees and their loved ones, and offers flexible work hours and paid time off, retirement contributions, financial and mental well-being resources, parental and family-building benefits, and travel support for safe healthcare services.

Requirements

• MD or equivalent, with foundational training in oncology, hematology, or a related subspecialty.
• Post-training clinical, academic, or early industry experience; qualifying years are counted after completion of a subspecialty fellowship.
• For Associate Medical Director level: 1–3 years of qualifying post-fellowship experience.
• For Medical Director level: 3–5+ years of qualifying post-fellowship experience.
• Direct experience with cancer genomics.
• Familiarity with clinical trial design, protocol development, or early-phase (Phase I/II) clinical development.
• Strong clinical intuition and comfort learning about diverse, low-incidence rare tumors and complex molecular landscapes.
• Ability to collaborate in a matrix-structured environment with multiple stakeholders and product lines, and translate technical medical and genomic concepts for non-clinical internal teams.
• Ability to manage multiple tasks concurrently, contribute to intermediate-complexity clinical data projects with guidance and mentorship, and meet ongoing deadlines in a fast-paced, technology-driven environment.
• Leadership, problem-solving, analytical, and communication skills, including the ability to multitask and prioritize.

Nice To Haves

• Exposure to laboratory translational oncology, cancer genomics, or biomarker discovery research.
• Prior scope of ownership in precision medicine relevant to level determination.

Responsibilities

• Serve as a core medical expert for high-volume custom data requests across oncologic diseases, including rare tumors and complex multi-omic biomarker profiles.
• Scope, design, and clinically validate custom datasets and analyses for biopharma partners across different disease areas.
• Partner with clients early in the R&D lifecycle to demonstrate how clinical-molecular datasets can support target discovery, biomarker-defined cohort characterization, tumor biology evaluation, and combination-therapy approaches.
• Help researchers validate preclinical hypotheses in real-world cohorts and explore clinical trial findings through reverse translation.
• Apply clinical-development and trial-design principles to help clients connect traditional clinical endpoints with real-world evidence.
• Advise on the use of real-world data for external control arms, historical cohorts, and synthetic control designs, including for niche or rare trial populations.
• Provide clinical and molecular data expertise for pre-sales, client scoping, and solution building, including use of internal or off-the-shelf external AI tools.
• Translate client development plans, target-validation needs, and complex inclusion and exclusion criteria into precise data specifications across company data assets.
• Work with matrixed project teams to apply clinical-molecular frameworks to complex dataset deliveries and custom client requests.
• Support development of internal training resources and clinical documentation to help delivery teams understand rare biomarker cohorts and molecular data structures.
• Participate in research study projects requiring physician expertise, with support from senior Research Oncology leaders, including presenting or speaking at scientific conferences.

Benefits

• Flexible work hours and flexible paid time off.
• Comprehensive compensation package.
• 401(k) contribution.
• One-to-one financial advice and other financial health resources.
• Mental well-being tools and services.
• Parental benefits and policies, including family-building care and generous leave.
• Fertility, adoption, and surrogacy support through path-to-parenthood programs.
• Travel support for safe healthcare services.
• Continuous learning and inclusion and belonging support.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree