Medical Director in Global Clinical Development Oncology

Merck•Billerica, MA

6d•Hybrid

About The Position

As a Medical Director in Global Clinical Development Oncology, you will provide clinical and scientific leadership for development programs in oncology, ideally with experience in targeted therapies, antibody-drug conjugates (ADCs), and/or immuno-oncology. Next to experience with drug development for solid tumors, experience with hematology/hematologic oncology is viewed favorably. In this role, you will independently drive day-to-day clinical development activities while contributing to high-quality execution of the overall clinical strategy in a global matrix environment.

Requirements

MD with expertise in clinical drug development
Required expertise in Oncology
Minimum 3 years of industry experience in clinical R&D within pharma/biotech
Experience supporting or leading clinical studies across Phase 1 through Phase III
Experience contributing to clinical development strategy, regulatory submissions, and registration-enabling activities
Familiarity with clinical dossiers, regulatory documentation, and Health Authority interactions
Demonstrated ability to integrate translational and biomarker data into clinical development decisions
Experience working in cross-functional, matrixed, and international teams
Familiarity with ICH-GCP, FDA and/or EMA expectations, and clinical trial regulations
Strong written and verbal communication skills in English
Ability to work independently, manage multiple priorities, and collaborate across time zones in an office-based environment.

Nice To Haves

Experience in targeted therapies, ADCs, immuno-oncology, and/or hematology/hematologic oncology
Experience across early and late clinical development
Experience contributing to study designs that support potential registration pathways
Experience with precision medicine, and/or biomarker-driven development
Strong project leadership skills with a track record of driving timelines and decision points
Board certification in Medical Oncology/Hematology or relevant subspecialty.

Responsibilities

Lead assigned clinical studies and contribute to broader program strategy across the development continuum, from Phase 1 through Phase III, including support for registration-enabling activities, regulatory submissions, and Health Authority interactions.
Integrate clinical, translational, biomarker, and emerging data to support indication strategy, patient selection, dose strategy, and key development decisions.
Operate as a core member of cross-functional teams and the Global Project Team, partnering closely with Program Leadership and Management, Translational Medicine, Biostatistics, Clinical Pharmacology, Regulatory Affairs, Clinical Operations, Safety, and Medical Writing.
Support study design, dose strategy, patient selection, and indication prioritization
Integrate clinical, translational, and biomarker data into development decisions
Provide medical monitoring and clinical oversight for assigned studies
Review and interpret safety and efficacy data to support study decisions
Author and contribute to key clinical and regulatory documents, including protocols, investigator brochures, clinical study reports, briefing books, submission documents, and dossiers
Contribute to registration-enabling activities and regulatory submissions
Support interactions with Health Authorities and internal governance bodies
Drive execution of deliverables across global teams and timelines
Contribute to a high-performing, collaborative matrix environment.