Medical Director/Senior Medical Director, Clinical Development (Prostate)
About The Position
ORIC Pharmaceuticals is seeking an experienced oncology physician to serve as a Medical Director or Senior Medical Director. This role provides medical leadership across one or more clinical development programs, with a primary focus on late-stage (registration-enabling) clinical trials. The position plays a critical role in shaping clinical strategy, ensuring scientific rigor, guiding regulatory interactions, and advancing programs from study design through regulatory submission. The Medical Director will work in close partnership with cross-functional teams including Clinical Operations, Regulatory Affairs, Biostatistics, Safety/Pharmacovigilance, Translational Medicine, and Medical Affairs. The role requires strong strategic thinking, hands-on execution, and the ability to lead effectively in a fast-paced biotech environment.
Requirements
- MD required
- Board certified or board eligible in Oncology or Hematology/Oncology
- 5+ years of experience in oncology clinical development, with increasing responsibility
- Demonstrated experience leading or contributing to late-phase oncology clinical trials
- Strong understanding of global clinical development pathways and regulatory requirements (FDA, EMA, ICH/GCP)
Nice To Haves
- experience in small-mid biotech environment is a plus
- particularly in prostate cancer is desired
- Familiarity with current medical practice in GU oncology with development experience is a major plus
- Prior experience as a principal investigator or academic clinician is a plus
Responsibilities
- Serve as the medical lead for one or more oncology programs across all phases of development
- Provide medical monitoring oversight for global clinical trials, including Phase 1–3 and registration-enabling studies.
- Act as the primary medical expert for internal teams and external stakeholders
- Represent the company in interactions with investigators, key opinion leaders, advisory boards, and regulatory authorities (e.g., FDA, EMA/CHMP)
- Partner with clinical scientists in the design and execution of clinical protocols, amendments, investigator brochures, study reports, abstracts, and manuscripts
- Partner with biostatistics to define study endpoints, statistical plans, and data analyses
- Ensure scientific rigor, data integrity, and patient-centric decision-making throughout development
- Maintain strong clinical and scientific competitive intelligence through ongoing engagement with the oncology community and key scientific meetings
- Work closely with Clinical Operations and CROs to support trial execution and operational excellence
- Collaborate with Regulatory Affairs on global regulatory strategy and submissions (e.g., INDs, NDAs, MAA)
- Partner with Safety/Pharmacovigilance to review adverse events, monitor safety signals, and support benefit-risk assessments
- Contribute to biomarker and translational strategies in collaboration with preclinical and translational teams
- Support investigator engagement, site training, and advisory board activities
- Contribute to abstracts, manuscripts, posters, and scientific presentations
- Participate in scientific conferences and external meetings as a medical representative of the company
- Lead and influence cross-functional teams in a matrixed environment
- Contribute to the overall clinical development strategy and culture of scientific excellence to ensure alignment with ORIC’s values, SOPs, and ethical standards
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
