Medical Director, Clinical Development

Olema Oncology • Boston, MA

5d • Onsite

About The Position

As the Medical Director, you will serve as an Oncology Physician for palazestrant and play a pivotal role in advancing Olema’s late and early-stage clinical pipeline in breast cancer. You will contribute to registration-enabling studies by shaping study design, evaluating clinical data, and engaging with regulatory authorities, investigators, and key opinion leaders. Partnering closely with experienced physicians and cross-functional teams, you will ensure scientific rigor, data integrity, and patient-centric decision-making while contributing to biomarker development, publication planning, and external scientific communications. This is a unique opportunity to contribute at a pivotal moment in the program’s trajectory and support the advancement of therapies for patients with ER-positive, HER2-negative breast cancer. This role will be based in Cambridge, MA and may require up to 20% travel.

Requirements

• MD (US Board Certified) is required
• Board certification in Oncology, Hematology/Oncology, or related specialty; significant academic or industry experience
• A minimum of 2+ years of direct biotech or pharmaceutical experience in clinical development, conducting clinical studies; strong Academic background may substitute
• Strong understanding of breast cancer treatment paradigms
• Experience in designing and managing clinical studies in oncology; strong experience as a PI or academic breast cancer expert is also valued
• Thorough understanding of the drug development process and ability to translate strategy into action—meeting milestones, and adapting to change
• Strong knowledge of GCP, FDA, and EMA/CHMP regulations; familiarity with other global regulatory standards is advantageous
• Demonstrated ability to operate effectively in a matrixed environment, influence without direct authority, and drive cross-functional alignment
• Exceptional communication skills—able to convey complex clinical data with clarity and purpose to both scientific and non-scientific audiences, verbal and written
• Demonstrated problem-solving ability with urgency, focus, and creativity
• Proven record of participating in collaborative, high-performing teams and partnerships
• Highly organized, detail-oriented, and adaptable to fast-paced, evolving priorities

Nice To Haves

• Thoughtful, decisive, and collaborative leader who inspires confidence and trust
• Systems thinker who can connect complex information, anticipate downstream impacts, and translate strategy into action
• Strong communicator who builds credibility with internal teams and external stakeholders
• A skilled relationship builder who thrives in a dynamic, mission-driven environment
• Committed to continuous learning, professional growth, and the development of others

Responsibilities

• Provide Medical Leadership and Expertise
• Contribute to registration-enabling studies for palazestrant in combination with other therapies, including study design, regulatory engagement, and investigator collaboration
• Partner across functions to define and implement clinical development strategies and plans for multiple programs
• Serve as the medical expert and point of contact for clinical and scientific questions across internal and external stakeholders
• Participate in interactions with investigators, academic collaborators, thought leaders, and regulatory authorities
• Maintain strong clinical and scientific acumen through ongoing engagement with the oncology community and key scientific meetings
• Design and Deliver High-Impact Clinical Studies
• Provide medical oversight and partner with CROs for the palazestrant program and ensure alignment with Olema’s values, SOPs, and ethical standards
• Contribute to the development and execution of clinical protocols, amendments, investigator brochures, study reports, abstracts, and manuscripts
• Ensure scientific rigor and data integrity in partnership with cross-functional internal teams (i.e. Clinical Operations, Biostatistics, Safety) and CRO teams
• Evaluate safety, pharmacology, and efficacy data from ongoing and completed studies to inform program strategy and decision-making
• Contribute to regulatory submissions and communications
• Collaborate with preclinical and translational scientists to develop and integrate biomarker strategies
• Support data generation, publication planning, and external communication of study results

Benefits

• competitive compensation and benefits package
• equity
• bonus

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree