Medical Director, Clinical Development (Oncology), Cambridge, MA

Isomorphic Labs•Cambridge, MA

9d•Hybrid

About The Position

Isomorphic Labs (IsoLabs) is developing and applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines. The company’s ambitious mission is to one day solve all disease. IsoLabs has built multiple cutting-edge AI models that power our unified drug design engine, which can tackle a broad spectrum of disease areas and modalities. This breakthrough technology will transform how we design new drug candidates and bring new potential medicines to patients. Come and be part of an interdisciplinary team driving groundbreaking innovation. You will play a meaningful role in achieving our ambitious goals, while being a part of an inspiring and collaborative culture. Together, let’s build the future of medicine at Isomorphic Labs. Isomorphic Labs was launched in 2021 to advance human health by building on and beyond the Nobel prize-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drug candidates will perform in the clinic and develop medicines to treat and cure some of the world’s most devastating diseases. At IsoLabs, we are committed to leveraging state-of-the-art AI to advance precision medicine paradigms and establish new benchmarks for both efficacy and safety by consistently delivering the optimal treatments to the appropriate patients at precisely the right time, which we expect to significantly enhance our overall probability of success. Isomorphic Labs is scaling globally, with headquarters in London and offices in Lausanne, Switzerland and a US base in Cambridge, Massachusetts. We continue to progress our internal candidate programs towards the clinic while advancing across a broad range of modalities including small molecules, molecular glues, peptides, and antibodies.

Requirements

MD or MD, PhD (or equivalent) in Oncology required; board certification preferred
Significant clinical development experience within the pharmaceutical or biotechnology industry, including experience in medical monitoring and leading cross-functional teams.
A proven track record of leading complex, cross-disciplinary projects from early-stage to clinical proof-of-concept.
Deep understanding of Oncology drug development and regulatory pathways.
Demonstrated ability to thrive in fast-paced, and evolving environments.
Exceptional ability to communicate complex clinical and strategic concepts to diverse audiences, including senior leadership, engineering teams, and external partners.

Nice To Haves

You are a natural problem solver who sees opportunity where others see uncertainty.
A strong interest in how AI and digital tools can be applied to drug discovery, safety monitoring, and patient stratification.

Responsibilities

Provide strategic medical leadership for the design, and execution of oncology clinical trials.
Collaborating closely with clinical operations to ensure clinical trials are in alignment with patient safety standards and in compliance with FDA, EMA, ICH and GCP guidelines while also ensuring that the overall scientific and medical content of all clinical programs is scientifically and clinically rigorous.
Serve as the medical expert and monitor for clinical studies, ensuring the highest standards of patient safety, data integrity, and protocol compliance.
Act as the primary point of medical contact for investigators, steering committees, and study teams.
Lead the clinical content for key regulatory submissions (INDs/BLAs).
Represent Isomorphic Labs in discussions with global health authorities and in peer-to-peer interactions with Key Opinion Leaders (KOLs) and clinical investigators.
Collaborate seamlessly with a cross-functional clinical development team to ensure development plans are both scientifically sound and clinically actionable.
Translating AI-driven insights into actionable clinical development strategies.
Serving as the primary medical monitor.
Leading cross-functional teams to advance therapeutic assets from discovery through clinical proof-of-concept.
Partnering with Clinical Operations to ensure the successful planning, execution, and implementation of clinical studies.
Serving as a subject matter expert.
Leading process improvement efforts.
Providing strategic medical guidance across various assets and indications.