Manager, Commercial Supply Chain Operations

Zenas BioPharma•Waltham, MA

12h•Hybrid

About The Position

The Manager, Commercial Supply Chain Operations is a hands-on, execution-focused role responsible for the day-to-day planning, scheduling, and operational coordination that keep Zenas’ commercial products flowing reliably across our external manufacturing and distribution network. Reporting to the Senior Director of Commercial Supply Chain Planning & Operations, the incumbent owns the tactical engine of commercial supply: finished goods planning and scheduling, inventory management and control, production schedule maintenance at CDMOs, and the coordination, shipping, and logistics required to keep inventory replenished and available. A central focus of this role is drug product (DP) to finished goods (FG) planning and scheduling. The incumbent will plan, coordinate, and track the progression from DP through packaging into finished goods. This person will bring proven, hands-on expertise in this area and a clear sense of what “good” looks like. This role works collaboratively across Technical Operations, Quality, and Commercial, and directly with CDMOs, 3PLs, and other external partners. Additionally, this role supports commercial supply planning and the Sales & Operations Planning (S&OP) process, responds to temperature excursions and shipping related issues, and helps build the tools, processes, and metrics needed to scale Zenas’ supply chain.

Requirements

Bachelor’s degree in Supply Chain, Engineering, Life Sciences, or a related field or equal combination education/experience.
Minimum of 5 years of hands-on supply chain experience in the pharmaceutical or biotechnology industry, with direct experience in commercial supply planning.
Direct, hands-on experience in the biologics space planning and scheduling the production of drug substance (DS) and drug product (DP).
Demonstrated, hands-on experience managing the packaging of finished goods and planning, coordinating, and tracking the DP-to-FG progression, including managing FG scheduling to maximize product shelf life following DP release.
Hands-on experience with inventory management and control across CDMOs and 3PLs in a GMP environment.
Shipping and logistics experience, including cold-chain distribution and coordination of material movements across the network.
Experience developing agentic capabilities using AI tools (e.g., Claude) to build automation, tooling, and reporting solutions.
Advanced proficiency in Excel and Smartsheet.
Working knowledge of GMP requirements, batch release, and the impact of temperature excursions and deviations on commercial supply.
Strong written and verbal communication skills, with a demonstrated ability to build and maintain strong relationships across internal functions and external partners.
Highly organized, detail-oriented, and able to work both independently and collaboratively in a fast-paced, matrixed environment.
Comfortable managing ambiguity and helping build new processes and tools from the ground up.

Responsibilities

Plan, coordinate, and manage the progression of drug product (DP) through packaging into finished goods, ensuring FG runs are scheduled and executed promptly upon DP release to maximize product shelf life and meet demand.
Manage and maintain finite production schedules at Zenas’ CDMOs, ensuring on-time manufacture, execution, testing, and release of DS, DP, and FG batches in alignment with forecast requirements and contractual commitments.
Own inventory management and control across the network of CDMOs and 3PLs, ensuring inventory targets are met and inventory is positioned to support reliable, uninterrupted supply.
Ensure timely and accurate reporting of inventory across the manufacturing and distribution network, maintaining visibility to inventory levels, batch status, material movements, and expiry.
Manage the shipping and logistics of product and material movements throughout the supply chain, coordinating shipments between manufacturing sites, CDMOs, warehouses, and 3PLs to ensure timely, compliant, and cost-effective distribution and the timely replenishment of inventory, including cold-chain and qualified-lane requirements.
Serve as a first responder to temperature excursions and deviations, partnering with Quality and external partners to assess impact, drive timely disposition, and support investigations and associated CAPAs.
Support commercial supply planning and provide inputs into the monthly S&OP process, surfacing supply risks, constraints, and recommended actions.
Work collaboratively with external partners, Quality, and Technical Operations to ensure GMP-compliant product availability, release, and distribution readiness.
Help implement and build tools and processes to scale and grow the supply chain, including leveraging AI and agentic capabilities to automate planning, reporting, and data workflows.
Support the tracking and reporting of key supply performance metrics (e.g., inventory coverage, batch on-time performance, plan adherence, expiry risk) to drive visibility, accountability, and continuous improvement.
Maintain clear, complete, and well-organized records across all areas of responsibility.
Other duties as required.