LC-MS Chemist - Metabolism

Labcorp•Madison, WI

2d•Onsite

About The Position

Labcorp is seeking an LC-MS Chemist – Metabolism to join our team in Madison, WI. This role involves organizing and performing routine to moderate-level method validation activities in compliance with SOPs and regulatory guidelines (GLP/GCP), executing advanced method validation tasks with guidance, and applying intermediate data interpretation and analytical instrumentation skills to resolve problems. The position also includes assisting in the review of reports and documentation, managing assigned project work, collaborating with colleagues, and training less experienced staff. Contributions to process improvement and maintaining a safe laboratory environment are also key aspects of this role.

Requirements

Bachelor's degree in Life Sciences, Chemistry, Biotechnology, or a related field.
1.5 or more years hands-on experience with LC-MS/MS bioanalysis, including MRM-based quantitation and method execution.
1.5 or more years of experience with ADME/PK assays such as liver microsomal stability, permeability assays (e.g., MDCK-MDR1), and PK sample processing (plasma, tissue lysates).
1.5 or more years operating triple quadrupole mass spectrometer platforms (e.g., Waters Xevo TQS, Agilent 6400 QQQ, SCIEX 5500, and SCIEX 6500).

Nice To Haves

1 or more years of exposure to CYP inhibition or Time-Dependent Inhibition (TDI) assays and drug-drug interaction (DDI) studies.
1 or more years of experience assisting in the development or optimization of new bioanalytical methods.
Master's degree or other post graduate studies in a relevant life sciences discipline.
Proficiency with data acquisition and processing software (MassLynx, MassHunter, Analyst, or equivalent).
Proficiency with ELN documentation, word processing, spreadsheet, and specialized analytical software.
Strong attention to detail with demonstrated ability to generate reproducible, high-quality bioanalytical data.
Familiarity with Orbitrap platforms or other high-resolution mass spectrometry systems.
Knowledge of regulatory guidelines including FDA, EMA, and ICH bioanalytical method validation guidance.
Experience working in a GLP/GCP-regulated environment (CRO or pharmaceutical/biotech industry).
Excellent written and verbal communication skills.
Proven ability to prioritize workloads and manage time effectively in a fast-paced laboratory environment.

Responsibilities

Organize and independently perform routine to moderate-level method validation activities in compliance with SOPs and regulatory guidelines (GLP/GCP).
Execute advanced method validation tasks with guidance from a Lead Scientist.
Apply intermediate data interpretation and analytical instrumentation skills to resolve procedural and scientific problems with minimal assistance.
Assist in the review of reports, methods, protocols, and SOPs; maintain complete and audit-ready study documentation.
Communicate problems, deviations, and corrective actions to Lead Scientist and/or management in a timely manner.
Manage assigned project work, coordinating activities with team members to deliver high-quality data to internal clients on schedule.
Collaborate effectively with colleagues across the Bioanalytical site and support cross-functional communications with external clients.
Train and mentor less experienced laboratory staff.
Contribute to process improvement initiatives and participate in department-wide quality initiatives.
Maintain a clean, safe, and organized laboratory environment.