LC/MS Analytical Chemist

Pace Analytical Services•Cambridge, MA

5d•Onsite

About The Position

The Scientist is responsible for performing advanced analytical development activities with a primary focus on hands-on operation of High-Resolution LC-MS instrumentation. This role develops and optimizes chromatographic (HPLC) and mass spectrometry-based methods to support the identification, characterization, and impurity profiling of siRNA molecules, formulations, and raw materials.

Requirements

Bachelor’s or Master’s degree in Chemistry, Biology, or related field
2-4 years of experience in a laboratory setting (GMP environment preferred)
Excellent organizational, attention to detail, and communication skills.
Able to handle multiple projects concurrently, self-motivated, and results driven

Nice To Haves

Experience with Agilent Q-ToF and the MassHunter software is the plus.
Proficiency in Office 365 and other software preferred

Responsibilities

Hands-on bench work using the High-Resolution LC-MS.
Development of chromatographic methods (HPLC) and mass spectrometric based assays for identification, characterization, and impurity determination of siRNA
Develop strategies for impurity profiling of new development candidates and raw materials.
Author method development and qualification reports and SOP’s for test methods.
Evaluate suitability of new methods, and assist method qualification and validation.
Contribute data to lead candidate testing, stability sample monitoring, OOS/deviation investigation and regulatory filing.
Understand and apply advanced scientific principles, theories, concepts, practices and standards to process and analytical development.
Follow training to independently operate instruments and carry out routine and non-routine analyses
Collaborate with internal and external teams to support project goals and meet research timelines