Laboratory Manager I - Booker Lab

Howard Hughes Medical Institute•Philadelphia, PA

2d•Onsite

About The Position

The Booker Lab at the University of Pennsylvania is a dynamic biochemical research group focused on understanding the mechanisms of radical S-adenosylmethionine (rSAM) enzymes and other metalloenzymes involved in complex biochemical transformations. The lab integrates enzymology, structural biology, mechanistic chemistry, and microbial metabolism to uncover how these systems function at the molecular level. In addition to its research mission, the lab maintains strong connections with HHMI and the broader university community, including involvement in training and mentorship initiatives. The Booker Lab is seeking a highly organized, collaborative, and proactive Lab Manager to oversee both technical and administrative operations in support of the lab’s research mission. This role is central to maintaining a productive, safe, and well-coordinated laboratory environment while enabling high-quality experimental work. The Lab Manager will serve as a key liaison between the lab, HHMI, and university administrative offices, managing budgeting, purchasing, compliance, and grant-related activities. This individual may also support or contribute to research projects, depending on background and experience. This position offers strong exposure to leadership, mentorship, and lab operations, and is well-suited for individuals interested in developing long-term careers in scientific research, administration, or academic leadership. The preferred start timeline for this position is June 2026. This is a full-time role, and flexibility is required to support time-sensitive lab needs, including occasional off-hours communication to ensure continuity of operations.

Requirements

Bachelor’s degree in biochemistry or a related field required
Three or more years of lab experience, including at least one year of supervisory experience
Strong operational knowledge of laboratory equipment and instrumentation
Proven ability to supervise, mentor, and support lab personnel
Excellent organizational and multitasking skills
Strong interpersonal and communication skills
Experience with grant coordination, budgeting, and administrative processes preferred
Ability to develop training materials and standard operating procedures
Strong problem-solving skills with the ability to improve systems and processes
Demonstrated initiative and ability to operate independently in a fast-paced environment

Nice To Haves

Advanced degree (Master’s or PhD) preferred
Experience with grant coordination, budgeting, and administrative processes preferred

Responsibilities

Lead day-to-day laboratory operations, including equipment oversight and supply management
Serve as primary liaison between the lab, HHMI, and university administrative offices
Oversee budgeting, purchasing, fixed asset tracking, and account management
Ensure compliance with institutional safety and regulatory guidelines
Develop and maintain SOPs, procedural manuals, and lab guidelines
Train and mentor incoming personnel in lab conduct, safety, and technical procedures
Provide day-to-day supervision and guidance to Research Technicians and junior staff
Coordinate grant submissions, including tracking deadlines and compiling required documentation
Evaluate and implement new technologies, workflows, and systems to improve lab efficiency
Support or contribute to research activities, including experimental coordination and data management