Laboratory Cell Profiling Research Scientist III - Chemical Insights Research Institute

UL Research Institutes•Research Triangle Park, NC

About The Position

We have an exciting opportunity for a Laboratory Cell Profiling Research Scientist III at UL Research Institutes Chemical Insights Research Institute (CIRI), based in our Research Triangle Park area facilities. The Laboratory Cell Profiling Research Scientist III, under general direction, assists in conducting laboratory toxicology research to support CIRI’s mission of advancing human and environmental health. This role primarily supports the generation of high-throughput high-content imaging (e.g., Cell Painting) data by performing laboratory experiments, generation, analysis, and interpretation of experimental data, operation and maintenance of laboratory equipment, and preparation of data summaries and written reports. This role may also support generation of in vitro transcriptomics (i.e., next generation sequencing) data in parallel. This role works under the supervision of and in collaboration with other research scientists to ensure that all laboratory experiments and measurements are accurate and technically sound. UL Research Institutes: At UL Research Institutes (ULRI), we expand the boundaries of safety science to create a more secure and sustainable world. For more than a century, we have studied the unintended consequences of innovation, designed solutions to mitigate risk and shared our findings with academia, scientists, manufacturers, and policymakers across industries. We identify critical safety and sustainability issues, asking the tough questions because we believe a safer world begins with knowledge. Build a safer, more secure, and sustainable future with us. Join us and work with our Chemical Insights team who conduct the research required to produce that knowledge and put into practice. Chemical Insights Research Institute (CIRI): The Chemical Insights Research Institute (CIRI) contributes to the protection of public health and well-being by conducting scientific research. Our research and initiatives let people around the world know what chemicals are in the air we breathe and how they affect human health and the planet. We share our research and knowledge through information and application tools with leaders in the scientific, business, and policy communities to raise awareness of human health risks stemming from emerging technologies. To learn more, visit: chemicalinsights.org/ What you’ll learn and achieve: As the Laboratory Cell Profiling Research Scientist III, you will play a key role in the rapid growth of UL as you:

Requirements

Working knowledge of cell culture, and associated techniques to enable use of a broad range of primary cells and cell lines.
Proficiency in high-throughput in vitro assay development and screening using high-content imaging and transcriptomic endpoints.
High attention to detail and documentation of laboratory procedures to support highly reproducible and reliable results.
Demonstrated ability to maintain and grow scientific and applied knowledge and skills.
Excellent communication skills, oral and written, are required.
Computational data analysis skills and ability to collaborate with a data analysis team.
Ability to collaborate with peers and work directly with Research Scientists and other team members in order to complete a project from start to finish.
Bachelor’s degree in biology, biochemistry, toxicology, or related field and minimum 8 years of directly related work experience or;
Master’s degree in biology, biochemistry, toxicology or related field and minimum of 4 years of directly related work experience or;
Doctoral degree in biology, biochemistry, toxicology or related field and a minimum of 2 years of directly related work experience.
Experience in high-throughput in vitro assay development and screening using high-content imaging across cell lines.
Experience with automated liquid handling, acoustic dispensing, and imaging platforms.
Experience managing high-dimensional data within a team of research and bioinformatic scientists.

Nice To Haves

Experience with transcriptomic endpoints across multiple cell lines is desirable but not required.

Responsibilities

Perform laboratory toxicology experiments and high-throughput screening studies aligned with CIRI’s mission.
Develop high-throughput in vitro assays that use high-content imaging to broadly profile biological processes and endpoints. May also support high-throughput transcriptomic data generation in tandem.
Lead segments of assay development, e.g., retrofitting of novel methods to introduce metabolic capacity or onboarding of new cell lines for specific chemical safety questions.
Lead projects designed within a team of research scientists to screen chemicals in the high-throughput in vitro assays to identify which chemicals may disrupt important biological processes and endpoints and inform threshold concentrations for bioactivity.
Prepare laboratory reagents and perform cell culture for in vitro assays using primary cells and cell lines.
Follow laboratory procedures, standard operating protocols, and organization safety and health requirements.
Communicate project outcomes with professional audiences in the technical field, including collaborative preparation of scientific reports, presentations, and peer-reviewed publications.
Perform basic maintenance of designated laboratory equipment and coordinate repairs.
Monitor laboratory inventory of chemicals, cell culture supplies, and reagents to ensure supplies are readily available and in stock.
Operate with minimal supervision within defined limits of responsibility and observe good laboratory practices.
Assist in writing research proposals and securing funding from internal and external sources.
Perform other duties as directed.

Benefits

All employees at UL Research Institutes are eligible for bonus compensation.
We offer comprehensive medical, dental, vision, and life insurance plans and a generous 401k matching structure of up to 5% of eligible pay.
Moreover, we invest an additional 4% into your retirement saving fund after your first year of continuous employment.
Depending on your role, you may be able to discuss flexible working arrangements with your manager.
We also provide employees with paid time off, including vacation, holiday, sick, and volunteer days.

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