Lab Manager

Orum TherapeuticsLexington, MA
$90,000 - $115,000Onsite

About The Position

Orum Therapeutics is a KOSDAQ-listed biotech pioneering degrader-antibody conjugate (DAC) therapies. Our Lexington lab is the operational core of our US R&D — and this role keeps it running. We're looking for a Lab Manager who walks in every morning asking "how can I help?" — and then goes and does it. This is a hands-on, high-ownership lab operations role supporting both the Chemistry and Biology teams. You'll oversee the day-to-day functioning of a ~9,000 sq ft research lab, manage a part-time Lab Associate who you'll help hire, and be the connective tissue between scientists, vendors, facilities, and finance. Chemistry instrument fluency is non-negotiable — HPLC, LC-MS/MS, and lyophilizers are mission-critical to our research and need a dedicated owner who can troubleshoot, not just schedule PMs.

Requirements

  • Experience with ELN systems (chemical inventory entry and management)
  • Familiarity with DOT/IATA shipping compliance and hazardous materials handling
  • Experience with Smartsheet or similar ops/ticketing tools
  • Prior experience hiring or supervising junior lab staff
  • Bachelor's degree in Chemistry or a closely related field — chemistry instrument fluency is the critical dependency for this role
  • 3+ years of lab operations or lab management experience in a biotech or pharma setting
  • Demonstrated hands-on experience with analytical chemistry instrumentation: HPLC, LC-MS/MS, lyophilizers, and nitrogen generators — must be comfortable troubleshooting, not just coordinating service calls
  • Strong organizational skills; able to manage competing priorities across multiple workstreams simultaneously
  • Service-oriented mindset — proactively identifies what's needed and acts without being asked
  • Comfortable operating at all levels of the task spectrum: from managing a vendor contract to helping receive a shipment

Responsibilities

  • Hire, onboard, and directly supervise a part-time Lab Associate; scope their role and co-design their responsibilities
  • Mentor the Lab Associate and support their development
  • Serve as the escalation point for lab ops issues across both chemistry and biology teams
  • Oversee common area cleanliness, organization, and decontamination of high-touch surfaces
  • Coordinate receipt of lab deliveries — open, inventory, and log incoming chemical and reagent shipments before distribution to scientists; maintain chemical inventory in the ELN
  • Manage glasswash and autoclave cycles
  • Order and stock consumables, PPE, and lab supplies; confirm scope of reagent ordering with science team leads
  • Own preventive maintenance scheduling for chemistry and biology instruments: LC-MS/MS, HPLC/UHPLC, lyophilizers, nitrogen generators, flow cytometers, CO2 incubators, plate readers, glassware washers, and cold storage
  • Troubleshoot equipment issues directly — not just escalate; chemistry instrument knowledge is the priority
  • Host service technician visits; manage service contract renewals
  • Maintain chemical inventory and emergency backup coverage for ELN entry
  • Willingness to learn LC-MS/MS monthly calibration (~4 hours/month) — not required at onboarding, but expected over time
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