Jr. Scientist II/X-Ray Crystallographer

Odyssey Systems Consulting Group, Ltd.•Silver Spring, MD

8d•$100,000 - $112,000•Onsite

About The Position

Odyssey is looking for a Jr. Scientist II, Xray Crystallography, to join a dynamic and growing team at the Walter Reed Army Institute of Research (WRAIR) Wound Infection Department (WID). WID is tasked with delivering specific, effective countermeasures for infection of combat wounds pre-injury, at the point-of-injury, and post-injury. The Structural Biology (XTAL) group focuses on structure-based drug designs for microbial pathogens of military relevance. Researchers in this group express, purify and crystallize ESKAPEE pathogen proteins of interest and utilize sophisticated techniques such as X-ray Crystallography and Mass Spectroscopy to model small molecule drug-protein interactions.

Requirements

Must be a US citizen or Green Card holder and lived in the U.S. three out of the last five years
Ability to Obtain NACI
Ph.D. in an appropriate discipline (e.g., microbiology, immunology, Molecular Biology or biochemistry)
At least three (3) years of experience in protein characterization and chemistry

Nice To Haves

NACI
Ph.D. in an appropriate discipline (e.g., microbiology, immunology, Molecular Biology or biochemistry)
3-5 years of experience in protein characterization and chemistry
Experience and training using BRUKER X-Ray Diffractometers.
Experience in at least one of the following areas: druggable target identification, cloning, enzymology, protein characterization and protein chemistry.
Strong computer skills and experience with relevant software, including MS Office and GraphPad Prism.
Experience with microbiology of Gram-negative negative species and antibacterial development is desired.
Must have a proven track record of securing competitive grant funding.
Must have excellent presentation and oral and written communication skills.
Ability to prioritize and work in a fast-paced and diverse environment. Contribute individually as well as part of a highly collaborative and productive team.
Must have proven ability to prepare precise technical summaries and protocols and maintain appropriate documentation.
Teamwork
Problem-Solving
Critical Thinking
Communication
Attention to Detail

Responsibilities

Be familiar with the field's concepts, practices, and procedures, including, but not limited to, microbiology, immunology, vaccinology, biochemistry, genetics, molecular biology, clinical trials, and bioinformatics.
Work independently and as part of a scientific team to understand and resolve complex biological questions while contributing to product development through the analysis and interpretation of data, presentation of data at meetings, the establishment of collaborations both internal and external to WRAIR, and the solicitation of grants and the writing of successful proposals.
Actively pursue the scientific objectives of the Branch and contribute significantly to the critical strategic planning and execution of future studies.
Design, develop and deliver novel small molecule antibiotics against MDR organisms of military relevance through structure-based drug design.
Identify novel small-molecule drug candidates through in silico screening of commercially available chemical databases and molecular modeling of drug candidates for enhancement.
Express, purify and crystallize proteins for structure-based drug design and perform mass spectrometry on all products.
Develop and recommend antimicrobial drug candidates for specific targets on MDR ESKAPEE pathogens (Enterococcus species, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae, and Escherichia coli).
Draft grant proposals on structure-based drug design for submission to leadership and research steering committees.
Conduct research on projects associated with antimicrobial development such as protein expression and purification, MIC (minimum inhibitory concentration) studies, animal modeling, virtual modeling of drugs bound to target proteins, etc.
Independently design experiments, make detailed observations, analyze data, interpret results and deliver timely results.
Mentor and supervise junior scientists within the team as needed.