In Vivo Research Associate II, Konermann Lab

Arc Institute • Palo Alto, CA

1d • Onsite

About The Position

We are seeking an In Vivo Research Associate II to join the Konermann Laboratory at the Arc Institute. You will collaborate closely with experienced scientists to advance in vivo projects focused on understanding brain development. This project builds on previous work in genome-scale CRISPR screening (Konermann et al., 2015; Biering et al., 2021; Wei et al., 2023; Roohani et al., 2025) and aims to combine modern functional genomics and neuroscience tools to investigate the molecular mechanisms underlying brain development and function. The ideal candidate will have experience in animal handling and colony management, intracerebral injections, sample processing for single-cell RNA sequencing and spatial pipelines, and imaging. This position offers an excellent opportunity for candidates considering PhD programs, as it involves participation in all stages of a research project under the guidance of an experienced scientist.

Requirements

• BS with 2+ years of relevant experience, or MS, in molecular biology, neuroscience, or another relevant field.
• Relevant experience includes independent lab work during undergraduate studies
• Strong experience working with laboratory animals, including handling, restraint, and procedures under an approved protocol (intracranial, IV, and IP injections, as well as perfusions)
• Detail-oriented, with excellent organizational and time-management skills
• Outstanding critical thinking and problem-solving skills
• Strong oral and written communication skills
• Highly motivated and curious, with the ability to work effectively both independently and as part of a collaborative team
• Ability to work some weekends as needed (days off can be swapped for weekdays

Nice To Haves

• Prior experience with cloning via Gibson assembly or Golden Gate protocols (library cloning experience is a plus)
• Knowledge of and experience with NGS library preparation, particularly single-cell and spatial workflows
• Computational skills (Python or R)

Responsibilities

• Plan, execute, analyze, and troubleshoot experiments with a high degree of independence, with continued support from the rest of the team
• Perform in vivo mouse experiments, including stereotactic surgeries, as well as IV and IP injections
• Collect and process tissue, including vibratome and/or cryostat sectioning, immunostaining, and imaging
• Comply with federal, Arc, and local IACUC/AAALAC regulations governing animal research
• Follow Arc's standards for code of conduct, safety, and the handling of hazardous materials, biological materials, and controlled substances
• Analyze and present data at subgroup meetings and seminars
• Maintain an organized, detailed lab notebook

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Associate degree