In Vitro Pharmacologist, CardioMetabolic Research

Lilly • Boston, MA

2d • $110,250 - $189,200 • Onsite

About The Position

Eli Lilly and Company is seeking a skilled, versatile scientist to join a collaborative drug discovery team in its CardioMetabolic Research organization in Boston. The organization discovers biologic, small-molecule, and genetic therapeutics for diabetes, obesity, and associated complications. This role will help advance discovery initiatives and pipeline projects focused on anti-obesity therapeutics by supporting assay development, validating novel targets, characterizing the in vitro function of novel therapeutics, establishing laboratory capabilities, and collaborating across departments to meet project and organizational objectives. The position is onsite at Lilly’s Seaport location in Boston, Massachusetts.

Requirements

• B.S. in Biology, Pharmacology, Biochemistry, or a related field.
• At least 5 years of laboratory experience in industry, academia, or biotechnology.

Nice To Haves

• Experience with native cell lines, primary cell cultures, and/or induced pluripotent stem cells (iPSCs).
• Master’s degree in biology, pharmacology, biochemistry, or a related field.
• At least 8 years of experience in industry or biotech.
• Experience with multiple therapeutic target classes, including membrane receptors such as G-protein-coupled receptors (GPCRs), ion channels, enzymes, and transporters.
• Experience with multiple therapeutic modalities, including small molecules, peptides, antibodies, and siRNAs.
• Experience with ELISA-based assays.
• Working knowledge of cardiometabolic disease biology and experience with new target proposals.
• Strong oral and written communication skills.
• Ability to work independently and collaborate effectively as part of a team.
• Strong attention to detail, accurate record-keeping, and ability to analyze data independently.
• Ability to prioritize and manage multiple projects, timelines, and organizational objectives.
• Willingness and ability to learn new technical skills and adapt to changing project requirements.
• Willingness to complete all required training in accordance with Lilly Research Policies.

Responsibilities

• Perform aseptic cell culture techniques using mammalian cells, including transient transfection and generation of stable cell lines.
• Develop, optimize, and execute cell-based functional, biochemical, and enzymatic assays, including ADP-Glo and Kinase-Glo assays, in 96- and 384-well formats and in single-concentration and concentration-response formats.
• Apply pharmacology principles to generate concentration-response curves and determine binding affinity, potency, Hill slope, and in vitro efficacy.
• Conduct mechanism-of-action studies, such as biased agonism, effects on receptor internalization, kinetic signaling, and Schild plots.
• Conduct assays using colorimetric, luminescence, and fluorescence-based readouts, including Homogeneous Time-Resolved Fluorescence (HTRF).
• Operate plate readers, liquid-handling robotics, and assay automation platforms.
• Perform gene expression analysis using quantitative PCR, western blot, and flow cytometry (FACS).

Benefits

• Company bonus, depending in part on company and individual performance.
• Eligibility to participate in a company-sponsored 401(k).
• Pension.
• Vacation benefits.
• Eligibility for medical, dental, vision, and prescription drug benefits.
• Flexible benefits, including healthcare and/or dependent day care flexible spending accounts.
• Life insurance and death benefits.
• Certain time off and leave of absence benefits.
• Well-being benefits, including an employee assistance program, fitness benefits, and employee clubs and activities.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level