Histotechnologist

Retro•Redwood City, CA

6d•$100,000 - $115,000

About The Position

Retro is hiring a Histotechnologist to join its growing histology core and support scientific programs including Microglia, Tissue Reprogramming, and Autophagy. The role performs FFPE and cryo-sectioning workflows from embedding through staining and imaging in a dedicated histology lab, as part of the Scientific Operations team. The successful candidate is an experienced bench histologist who produces high-quality sections and stains, works independently, manages requests from multiple teams, and helps build workflows. They communicate with scientists about tissue needs and advise on best practices from fixation through imaging. The position is generally aligned with the level of Histology Specialist. Retro states that it does not use titles internally; new hires join as a “Member of X Team.”

Requirements

At least 5 years of hands-on histology experience with FFPE and fresh-frozen workflows, including embedding, microtomy, and staining.
Proficiency in paraffin sectioning and cryosectioning.
Experience with IHC and/or IF staining, including antibody titration and protocol troubleshooting.
Demonstrated ability to work independently and manage multiple concurrent requests.
Organized and detail-oriented, with the ability to maintain clean records and a clean lab.
Clear and effective communication skills.
Proactive, hands-on approach to work.

Nice To Haves

Experience with multiplex staining techniques.
Start-up experience or experience in resource-constrained environments.
Experience in GLP or regulated laboratory environments.

Responsibilities

Independently execute day-to-day histology workflows, managing prioritization, quality control, and turnaround timelines.
Partner with the histology lead and scientific teams to triage and schedule work across programs, communicate timelines, flag conflicts, track sample throughput, and maintain organized records.
Perform tissue and organoid embedding, paraffin and frozen sectioning, vibratome sectioning, and slide preparation.
Conduct IHC and IF staining, including protocol optimization and new antibody validation.
Perform H&E staining and special stains as needed.
Support the development and documentation of SOPs for histology workflows.
Operate and maintain histology equipment, including an embedding center, microtome, cryostat, vibratome, water baths, fume hood, and associated instruments.
Coordinate with CROs on tissue processing and ensure the quality of incoming processed tissues.
Decalcify tissues as needed for bone or calcified samples.
Assist with imaging stained sections or coordinate imaging support with instrument engineers.
Manage histology supplies inventory, ordering, and lab organization.
Advise scientists on tissue collection, fixation, and handling best practices to support downstream quality.