High Throughput Screening/ Bioanalytical Associate Scientist

Excelsior Sciences of New York•New York, NY

3d•$80,000 - $120,000•Onsite

About The Position

Excelsior Sciences of New York is transforming small molecule therapeutic drug discovery with the use of modular chemistry, to make better medicines fast. Excelsior's modular approach leverages smart blocks as the foundation of drug design and synthesis. Our smart blocks and proprietary methodologies enable chemistry that machines can do, rather than building machines that attempt to do chemistry as it is practiced today. By coupling our automated synthesis and testing, we can reduce the design-make-test-analyze cycle to two weeks. This rapid generation of high-quality data allows us to fully leverage AI/ML to create closed learning loops and conduct multiparameter optimization, resulting in better medicines, fast. Excelsior's operations are fully U.S.-based, as our automated approach enables us to onshore integrated drug discovery. We are seeking a highly skilled bioanalytical scientist with a strong background in LC/MS for small molecule ADME analysis to join our team. This is a laboratory-based role to profile new leads and advance novel small molecule therapeutics across multiple modalities and disease areas. This role involves following SOPs, reagent preparation and operating the High Throughput Automated Screening Systems for lead discovery.

Requirements

Bachelor's or Master's degree in Analytical/Pharmaceutical Sciences, ADME (Absorption, Distribution, Metabolism, and Excretion), or a related field.
1-2 years of experience working with LC-MS systems (preferably Agilent systems) ideally with applications for ADME assays
Knowledge in LC-MS software and data analysis tools.
Demonstrated analytical and problem-solving skills.
Ability to work independently and collaboratively in a team environment.
Strong communication and interpersonal skills.

Nice To Haves

Experience with liquid handlers or automation.
Working knowledge of software tools from Agilent (OpenLab, MassHunter) and Virscidian.
Expertise in small molecule screening and analysis
Experience in data management and analysis
Experience with writing scientific reports and presenting data.

Responsibilities

Operate and maintain Mass Spectrometers, ensuring optimal performance and troubleshooting issues as needed.
Follow SOPs for data analysis, including peak picking, mass spectral deconvolution, and support interpretation of results.
Prepare samples for high throughput LC/MS analysis, ensuring compatibility with MS systems.
Carry out routine and preventative maintenance and minor repairs, coordinate more complex service, of analytical equipment to ensure uninterrupted lab activities.
Prepare and maintain inventory of reagents and consumables and perform assays on automation platform
Document study protocols/findings and contribute to study report authorship.
Use of electronic documentation of analytical results, methods, and instrument performance. Communicate project status and issues to the management and other stakeholders.
Ensure compliance with laboratory safety protocols and regulatory standards.