Head of R&D Portfolio & Project Management

IlluminaSan Diego, CA
$205,100 - $307,700Hybrid

About The Position

The Head of R&D Portfolio & Project Management Office (PMO) is accountable for execution excellence across a complex and evolving R&D portfolio. Reporting into the Senior Director of R&D Strategy & Portfolio, this role leads and advances best‑in‑class portfolio, program, and project management capabilities to enable disciplined delivery, predictable outcomes, and transparent execution across R&D. This leader owns the design, deployment, and continuous improvement of scalable PMO practices, including delivery standards, governance models, and enabling tools. In close partnership with R&D Strategy & Portfolio, the role translates portfolio priorities into integrated execution plans, sequencing, and delivery insights that support effective trade‑offs and decision‑making. This role also builds and sustains strong PMO talent to support increasingly complex, cross‑functional R&D initiatives.

Requirements

  • Advanced degree in Life Sciences, Business, or related field; MBA or PhD preferred.
  • 12-15+ years of experience in R&D portfolio / project management and operations leadership
  • Demonstrated success building PMO capabilities, strengthening delivery performance, and developing PMO talent
  • Experience running development programs that include different product types: instruments, assays, regulated products, and software
  • Advanced understanding of stage-gate product development process and risk management
  • Strong communication, leadership and stakeholder management skills effective in matrixed organizations
  • Ability to work independently and collaboratively across all levels of the organization
  • Positive change agent – experience leading effective change management practices
  • PMP or similar certification preferred

Responsibilities

  • Lead the R&D PMO to ensure execution rigor, predictable delivery, and operational discipline across a complex R&D portfolio
  • Ensure initiatives are delivered on time, on budget, and to defined quality standards, with strong risk and dependency management
  • Own and continuously improve PMO standards, methodologies, governance and tools, including fit-for-purpose product development and delivery frameworks
  • Integrate AI into PMO processes to increase overall project delivery efficiency
  • Enable effective portfolio governance in partnership with R&D Strategy and Portfolio Operations & Insights, Corporate Strategy, Product Management, and business group leaders
  • Operationalize portfolio priorities into executable programs, roadmaps, and capacity-informed plans
  • Provide execution-based insights to inform portfolio trade-offs, sequencing, and governance decisions
  • Deliver clear, consistent execution reporting, dashboards, and metrics to R&D leadership and cross-functional leadership
  • Serve as trusted execution partner to senior executives and cross-functional leaders, in a complex matrixed environment
  • Drive cross-R&D alignment and collaboration to manage interdependencies and accelerate delivery
  • Champion transparency and accountability through effective reporting and insights
  • Attract, develop, and retain top-tier PMO and R&D talent
  • Coach and mentor PM talent to strengthen core competencies and career progression
  • Foster a high-performing, inclusive culture focused on innovation, adaptability, and measurable outcomes

Benefits

  • access to genomics sequencing
  • family planning
  • health/dental/vision
  • retirement benefits
  • paid time off
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