Head of DMPK

Edison Scientific • San Francisco, CA

5d • Onsite

About The Position

Edison Scientific builds and commercializes AI agents for science. Scientific discovery moves too slowly, and autonomous AI agents are how we intend to fix that. We're assembling a team of top researchers and engineers across AI and biology to build an AI scientist.

We're looking for a DMPK Specialist to join the Edison team as Head of DMPK. You'll own the scientific integrity of our agentic DMPK pipeline, setting the standard for every AI-generated PK analysis, ADME interpretation, human dose projection, and IND DMPK report section we ship. Beyond maintaining rigor, you'll define and implement the scientific approaches that train and evolve our AI agents over time, with the potential to shape how DMPK is practiced across the AI industry.

This role will report to the Head of Science.This role is on-site at our San Francisco office in the Dogpatch neighborhood. Our office is a converted warehouse with high ceilings, open space, and a team that genuinely believes in what they're building.

Requirements

• 10+ years of hands-on DMPK experience supporting programs from discovery through IND, or direct ownership of 10+ IND-reaching programs.
• Proven ability to translate CRO bioanalytical data, in vitro ADME results, and in vivo PK study reports into FDA-ready IND DMPK submissions.
• Strong proficiency in PK modeling. Experience with at least one PBPK platform (Simcyp, GastroPlus, or PK-Sim).
• End-to-end ADME fluency.
• Comfortable operating as the sole in-house DMPK expert with minimal supervision.
• Enthusiastic about iterating with LLM tools to identify data sources and improve agent outputs.

Nice To Haves

• Experience leading regulatory DDI strategy, including PBPK-based DDI predictions submitted to FDA/EMA.
• PK/PD modeling or quantitative systems pharmacology (QSP) experience.
• Previous AI/ML work applied to DMPK or ADME property prediction.
• Background at big pharma or CROs supporting large pharma IND programs.

Responsibilities

• Generate and architect high-quality DMPK training data spanning the discovery-to-IND workflow, in vitro ADME panels, in vivo PK across preclinical species, metabolite identification, NCA outputs, and PBPK/population PK simulations.
• Identify optimal data sources, synthetic generation, consortia, licensed datasets, public PK/ADME databases, and beyond.
• Evaluate and validate AI-generated DMPK outputs (PK parameter estimates, model fits, ADME interpretations, dose projections, written report sections) for scientific accuracy and regulatory compliance.
• Collaborate with Engineering, Evals, and Science teams to benchmark and improve agent performance against gold-standard DMPK workflows.
• Direct and improve agent logic to refine data quality and agent capabilities.

Benefits

• Competitive salary and equity
• Full healthcare coverage — we pay 100% of premiums for you and your dependents
• Support for growing families, including a yearly new parent stipend and fertility coverage through Carrot
• 401(k) company matching
• $300 health and wellness benefit per quarter
• Lunch is on us every day you're in the office, and dinner is on us when you're working late
• Regular team offsites and company events

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: No Education Listed