gRNA Process Development Scientist
Eurofins•Boston, MA
•$32 - $41•Onsite
About The Position
We are seeking a process development scientist to join the guide-RNA (gRNA) process development team. The successful candidate will be contributing to gRNA drug substance process development for programs in clinical development. In this role, the candidate will synthesize, purify, and characterize gRNAs in an effort to develop drug substance manufacturing processes and controls.
Requirements
- B.S./M.S. degree in chemistry, chemical engineering, or biochemistry (or related field) with at least 2 years of relevant laboratory industry experience
- Experience with oligonucleotide synthesis and purification equipment (experience with gRNA or longmer synthesis and purification development is a plus)
- Experience operating analytical equipment such as Akta chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.
- Experience with Tangital Flow Filtration (TFF) is required.
- Ability to follow established SOPs for routine analytical support.
- Experience with good documentation practices and electronic lab notebooks such as Benchling.
- Unwavering commitment to safety protocols and procedures.
- Strong attention to detail, organizational, and time-management skills.
- Effective communication skills for collaborating with team members and conveying technical information clearly.
- Strong problem-solving abilities and critical thinking skills.
- Inquisitive, analytical, laboratory technique familiarity, enthusiasm to learn and contribute in a fast-paced environment.
Nice To Haves
- Background in CRISPR gRNA development.
- Authorization to work in the United States indefinitely without restriction or sponsorship.
Responsibilities
- Execute solid-phase synthesis and purification experiments to support process development, scale-up, and transfer of oligonucleotide drug substance manufacturing.
- Execute routine analytics including HPLC and UV-Vis.
- Prepare buffers, reagents, and stock solutions used for process development activities, following established recipes and SOPs.
- Compile and present data to team members and key stakeholders
- Maintain an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed.
- Uphold lab safety to the highest level of standards.
Benefits
- Comprehensive medical coverage, dental, and vision options
- Life and disability insurance
- 401(k) with company match
- Paid vacation and holidays
- Eligibility for yearly goal-based bonus & merit-based increases
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Associate degree
