Global Medical Director, Medical Affairs

Dyne Therapeutics•Waltham, MA

3d•$215,000 - $260,000•Onsite

About The Position

The Global Medical Director, Medical Affairs serves as a strategic Global Medical Affairs Lead for Dyne’s programs, with responsibility for developing and executing integrated global medical plans that advance scientific understanding, evidence generation, external engagement, and launch readiness. This role represents Global Medical Affairs on highly visible cross-functional teams, including Program Teams, Clinical Development sub-teams, evidence generation forums, launch readiness workstreams, and future Brand Teams. This individual translates clinical and scientific insights into actionable medical strategies, supports congress, symposia, advisory board, publication, medical education, and evidence generation activities, and helps strengthen Dyne’s external scientific presence with healthcare professionals, key opinion leaders, payers, patient communities, and other stakeholders. The Global Medical Director partners closely with Clinical Development, Clinical Operations, Regulatory Affairs, Scientific and Medical Communications, Value and Access, Commercial, Patient Advocacy, regional medical teams, and external experts to ensure medical plans are aligned with corporate, program, product, and regional priorities. The role also supports trial site engagement, patient journey and diagnostic pathway work, Target Product Profile development, payer and access planning, data gap assessment, insight generation, and medical input for partnered assets, as needed.

Requirements

Advanced scientific or clinical degree required; MD, PhD, PharmD, or equivalent doctoral degree preferred
10+ years of relevant experience with 6+ in industry years of relevant experience in Medical Affairs, Clinical Development, Scientific Communications, or related roles within the pharmaceutical or biotechnology industry
Experience in rare disease required; neuromuscular disease, genetic medicines, oligonucleotide therapeutics, ASOs, or related therapeutic areas strongly preferred
Demonstrated ability to develop and execute medical strategies, global medical plans, evidence generation plans, KOL engagement strategies, congress plans, and publication or medical education activities
Strong scientific acumen with the ability to interpret clinical, nonclinical, biomarker, real-world, and competitive data and translate insights into clear medical recommendations
Experience working effectively on cross-functional asset, program, launch readiness, or brand teams in a matrixed organization
Proven ability to build credible relationships with KOLs, healthcare professionals, investigators, payers, patient advocacy partners, and other external stakeholders
Excellent written, verbal, and presentation skills with the ability to communicate complex scientific and medical information clearly to internal and external audiences
Strong collaboration, influencing, prioritization, and problem-solving skills, with the ability to drive alignment and execution without direct authority
Ability to operate with urgency, sound judgment, accountability, and flexibility in a fast-paced, growing biotechnology company
Working knowledge of applicable medical affairs, compliance, regulatory, and scientific exchange standards
Willingness to travel as needed for congresses, advisory boards, investigator or site engagement, external expert meetings, and internal meetings
Positive team member who embodies Dyne’s core values and demonstrates strong commitment to patients, scientific integrity, and compliance
Candidates must be authorized to work in the United States

Responsibilities

Serve as the Global Medical Affairs representative and strategic medical lead on cross-functional teams supporting assigned neuromuscular disease programs
Develop and execute integrated global medical plans aligned with corporate, program, product, evidence generation, and launch readiness priorities
Act as a medical and scientific subject matter expert on Dyne’s FORCE platform, oligonucleotide and other relevant therapeutic modalities, and the scientific, clinical, diagnostic, and treatment landscape for assigned neuromuscular programs
Maintain deep knowledge of scientific literature, clinical data, competitive intelligence, diagnostic pathways, treatment landscapes, patient journeys, and unmet needs for assigned programs
Lead or support global KOL, payer, investigator, and external expert engagement strategies, including landscape mapping, engagement planning, insight gathering, synthesis, and reporting
Partner with Clinical Development, Clinical Operations, Regulatory Affairs, Biometrics, Translational Medicine, and Program Leadership to support clinical trial planning, site engagement, data interpretation, and medical input into program strategy
Identify medical evidence gaps and support development of evidence generation strategies, including real-world evidence, investigator-sponsored research areas of interest, post hoc analyses, natural history, registry, and other medical research initiatives
Collaborate with Scientific and Medical Communications to support publication strategy, congress planning, symposia, medical education, abstracts, posters, presentations, field medical resources, and other scientific communications
Partner with Value and Access, Commercial, New Product Planning, Patient Advocacy, and regional medical teams to inform TPP development, patient identification efforts, patient journey mapping, payer engagement plans, and launch readiness activities
Ensure regional and field medical teams have the scientific context, resources, and aligned messaging needed to engage external stakeholders compliantly and effectively
Translate external insights and emerging data into clear recommendations that inform global medical strategy, lifecycle planning, and cross-functional decision-making
Support advisory boards, expert panels, congress activities, medical education programs, and other external engagements in accordance with Dyne policies and applicable regulations
Contribute medical input to internal and external materials, as appropriate, ensuring scientific accuracy, consistency, and compliance
Support partnered assets and business development activities, as needed, by providing medical affairs perspective and scientific insight
Model integrity, accountability, collaboration, scientific excellence, and compliance in all internal and external interactions