Global Medical Affairs Leader (Breast Cancer)

AstraZeneca • Gaithersburg, MD

1d • $206,827 - $310,241

About The Position

The Global Medical Affairs Lead (GMAL) is a pivotal strategic leadership role within AstraZeneca’s Oncology Business Unit (OBU). This position sits at the heart of AstraZeneca’s ambition to deliver 61 new indication launches and transform cancer care globally. GMALs drive the scientific and strategic agenda that advances patient experience, closes care gaps, and promotes health equity, ultimately enabling AstraZeneca to be recognized as #1 in Oncology. As the accountable strategic medical leader for assigned indication(s)/asset(s), the GMAL shapes and delivers the Global Medical Strategy, acts as the critical bridge between R&D and Commercial, and leads the global medical launch readiness journey. The role balances excellence in evidence generation and confidence building, scaling AZ’s impact without increasing organizational complexity.

Requirements

• Advanced degree required (MD, PhD, PharmD, or equivalent scientific degree).
• Significant experience in Medical Affairs (~ 7yrs) within the pharmaceutical or biotech industry, ideally at the country, Region and global level.
• Demonstrated success in leading evidence generation strategies, Medical Plans, publications, or scientific communication programs.
• Proven ability to influence senior stakeholders across Commercial, R&D, and Medical Affairs.
• Experience engaging external experts and scientific communities.

Nice To Haves

• Previous global Medical Affairs leadership experience in oncology.
• Experience leading cross‑functional teams in highly complex, multi‑indication environments.
• Experience navigating launch environments, new MoAs, new CDx, complex biomarker landscapes, or challenging safety profiles (aligning to GMAL complexity criteria).

Responsibilities

• Lead development, evolution, and delivery of the Global Medical Plan for assigned oncology indication(s)/asset(s).
• Set strategic direction, prioritize initiatives, and make evidence‑based trade‑offs to maximize patient and business impact.
• Proactively adjust the medical strategy in response to external dynamics, insights, and performance against launch KPIs.
• Define and track Key Performance Indicators (KPIs) to measure medical strategy impact, identify progress, and diagnose blockers to launch success.
• Represent Global Medical on critical cross‑functional forums: Integrated Business Team (IBT) shaping Commercial strategy, Global Product Team (GPT) informing R&D development, evidence requirements, and lifecycle planning.
• Lead Medical Integrated Teams (MITs) to align global, regional, and country teams around launch strategies and execution.
• Serve as a medical decision‑maker and ambassador in market engagements, addressing insight needs, resolving misalignment, and reinforcing global priorities.
• Represent Global Medical in Launch Readiness Reviews and Strategic Brand Reviews, elevating Medical Affairs’ role and impact.
• Ensure Medical input shapes Clinical development (e.g., registrational evidence gaps, companion study needs, Target Product Profiles) and Commercialization strategies (e.g., Tumor Strategic Plans, Business Strategy Plans).
• Strengthening global medical capabilities through effective delegation, coaching, empowerment, and mentorship.
• Lead global and regional gap analyses to identify critical clinical, RWE, and mechanistic evidence needs.
• Develop cross‑functional, integrated evidence plans spanning clinical, diagnostic, digital, and real‑world sources.
• Shape the scientific and strategic design of AZ‑sponsored interventional Medical Affairs studies and own relevant protocol elements.
• Conceptualize RWE studies with O2R and ensure alignment with broader evidence strategy.
• Oversee study governance, milestones, and resource allocation to ensure delivery to the highest scientific, ethical, and compliance standards.
• Develop and own the Global Publications Plan from Phase 3 ID onwards in partnership with the publications team.
• Prepare and deliver compelling scientific communications, ensuring compliance and credibility.
• Review and approve selected local/regional medical studies and Externally Sponsored Research (ESR).
• Ensure the MARS vision is fully reflected across evidence activities—leveraging cancer networks, innovative study design, and data‑driven insights.
• Own and lead the scientific narrative beginning 4 months prior to Phase 3 ID, ensuring scientific consistency across evidence, publications, congresses, and education.
• Build accountability for the Integrated Confidence Plan, while CoEs deliver execution.
• Define educational priorities and provide subject matter expertise ensuring alignment to the scientific narrative.
• Identify priority audiences, learning objectives, and delivery formats (e.g., digital, hybrid, in‑person).
• Ensure scientific rigor and excellence in global medical education delivered by MedEx and other partners.
• Lead the external engagement strategy for the indication(s)/asset(s), including KEEs, societies, health systems, and global organizations.
• Leverage local and global partnerships to gather actionable insights and shape scientific and clinical practice.
• Actively influence external experts to advance health outcomes and accelerate guideline adoption.
• Lead the congress strategy and guide operational preparation: Pre‑congress (abstracts, presentations, training), Post‑congress (insight synthesis, dissemination, follow‑up).

Benefits

• 401(k) plan
• Paid vacation and holidays
• Paid leaves
• Health benefits including medical, prescription drug, dental, and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Senior