Global Commercial Director, Breast Cancer (ADCs)

AstraZeneca • Gaithersburg, MD

3d • Hybrid

About The Position

At AstraZeneca, we are dedicated to transforming ideas into life-changing medicines, particularly in oncology. We are leading a revolution in cancer care to address unmet patient needs by understanding cancer's complexities to discover, develop, and deliver treatments. The Oncology business is the fastest-growing segment in the industry, boasting a diverse portfolio and pipeline. Franchise teams are crucial in driving launch and commercial effectiveness, shaping the cancer care landscape. The Global Commercial Director will be a vital member of the Breast Cancer Franchise, contributing to transforming cancer care globally. This strategic role, reporting to the Global Commercial Head, is responsible for developing and executing the global strategy for multiple indications, driving significant regional growth. The Director will collaborate closely with global country and regional leads in the US, Europe, and Asia, as well as various headquarter functions. This position is based in Gaithersburg, MD, requiring three days a week onsite.

Requirements

• Over 10 years of experience in pharmaceutical development and commercialization.
• At least 5 years in marketing, strategy, or life sciences consulting.
• Strong Oncology background, with experience in multiple commercial roles for a large/mid-sized pharmaceutical company to drive launch and in-line performance.
• Proven track record in global brand strategy and launch execution.
• Strong strategic thinking, judgment, and influencing skills to lead across regions and markets with clear financial accountability.
• Robust business acumen (forecasting, insights, competition) and problem-solving skills.
• Strong experience in pre-launch and in-line brand management.
• Demonstrated ability to lead in a matrix environment and influence without authority.
• Experience working with cross-functional teams (Medical, Access, Insights, etc.).
• Excellent communication and stakeholder management skills.

Nice To Haves

• MBA in a relevant field
• Sales/Customer-facing experience
• Management experience
• Successfully launched brands at a global level
• Experience working in Breast Cancer
• Experience working in a commercial alliance/partnership environment

Responsibilities

• Lead the creation, execution, and continuous refinement of the commercial brand strategy for key indications in HER2+ metastatic breast cancer, ensuring robust lifecycle management from prelaunch through postlaunch.
• Achieve clear differentiation and competitive positioning against emerging and established players.
• Own global commercial leadership of a critical brand launch, ensuring sustained performance and delivery against strategic and financial objectives.
• Act as indication lead in senior forums, communicating commercial performance, financial outlooks, and investment trade-offs to senior executives and governance committees.
• Partner with Regional and Country teams as a key member of Integrated Brand Teams to set clear priorities, drive accountability, and ensure coordinated delivery across functions for launch excellence.
• Deliver marketing strategies that ensure successful launches and maintain strong post-launch momentum.
• Collaborate with global cross-functional teams, including Medical Affairs, Insights and Analytics, and Market Access, to achieve global ambitions and ensure alignment.
• Engage regional and key market stakeholders to drive launch readiness, build capabilities, and ensure effective deployment of global and local budgets.
• Partner effectively with cross-functional Alliance colleagues to co-develop strategy and launch plans.
• Lead all aspects of post-launch performance by monitoring uptake, access, and executional efficiency, initiating data-driven course corrections, and reallocating resources.
• Hold global budget accountability for key indications, including the development of the annual operating plan, budget phasing, and investment prioritization.
• Maximize value across pre-launch, launch, and in-line phases, across regions.
• Represent and articulate the commercial and marketing strategic vision for key indications within the Global Product Team (GPT), influencing critical decisions and trade-offs.

Benefits

• Qualified retirement program (401(k) plan)
• Paid vacation and holidays
• Paid leaves
• Health benefits including medical, prescription drug, dental, and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Senior