General Supervisor, Oncology

BillionToOne•Menlo Park, CA

1d•Onsite

About The Position

BillionToOne is seeking a Clinical Laboratory General Supervisor (GS) to support our Oncology product, Northstar, in a high-complexity CLIA laboratory environment. This role provides general supervision of personnel and daily laboratory operations, ensuring regulatory compliance, quality, and operational excellence across end-to-end cancer blood sample processing. This is a hands-on leadership role in a fast-growing, high-throughput molecular diagnostics lab. The General Supervisor will serve as a key operational leader and first point of escalation for CLS and CLA, partnering closely with the Technical Supervisor, Laboratory Director, and Quality team. This is an onsite position supporting the Monday–Friday Mid Shift (11:30 AM – 8:00 PM), with a planned transition to a PM shift (3:00 PM – 11:30 PM) later this year.

Requirements

Active California Clinical Laboratory Scientist (CLS) license (or CGMBS/generalist license) meeting CLIA requirements for high-complexity testing
Bachelor’s degree in chemical, biological, physical, clinical laboratory science, or a related field
Minimum 4 years of clinical laboratory experience, including molecular and/or high-complexity testing
Meets CLIA General Supervisor qualifications under 42 CFR 493.1461, including appropriate education, training, and experience
Demonstrated hands-on experience with molecular biology techniques (e.g., DNA extraction, PCR, automated liquid handlers)
Strong working knowledge of LIMS, quality systems, and laboratory documentation
Proficiency with Google Docs, Excel, Word, and basic statistical analysis
Excellent attention to detail, organizational skills, and ability to perform under time-sensitive conditions
Strong written and verbal communication skills and a collaborative leadership style

Nice To Haves

Prior experience serving as a CLIA General Supervisor
Startup or high-growth laboratory experience
Background in medical genetics or oncology diagnostics
Experience working with cell-free DNA (cfDNA) or next-generation sequencing workflows

Responsibilities

Serve as a designated CLIA General Supervisor for high-complexity testing in accordance with 42 CFR Part 493 and CAP accreditation standards
Provide day-to-day supervision of laboratory personnel, including CLSs and CLAs, during the pre-analytic, analytic, and post-analytic phases of testing
Act as the primary escalation point for technical, operational, and personnel issues during assigned shifts
Oversee staffing, scheduling, shift handoffs, and workload distribution to ensure operational continuity
Perform and oversee high-complexity molecular oncology assays, supporting diagnostic testing for patient care
Ensure proper instrument operation, calibration, maintenance, and troubleshooting
Review, interpret, and verify test results and quality control data
Identify, investigate, and resolve deviations that may impact test performance or result integrity
Ensure compliance with CLIA, CAP, state, and local regulatory requirements
Perform, review, and document quality control, corrective actions, and preventive maintenance
Participate in inspection readiness, audits, and regulatory responses
Lead or support SOP development, review, and biennial updates
Lead training, onboarding, and competency assessments for new and existing laboratory staff
Provide hands-on and theoretical training for new assays, processes, and instrumentation
Support process improvement initiatives, including assay validation, tech transfer, and troubleshooting
Partner cross-functionally with Quality, R&D, and Operations to drive continuous improvement

Benefits

Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
Open, transparent culture that includes weekly Town Hall meetings
The ability to indirectly or directly change the lives of hundreds of thousands patients
Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
Supplemental fertility benefits coverage
Retirement savings program including a 4% Company match
Increase paid time off with increased tenure
Latest and greatest hardware (laptop, lab equipment, facilities)
Daily on-site lunches provided from top eateries
A variety of perks on campus (state of the art gym, restaurant)
Free on-site EV charging (compatible with all EVs, including Tesla)
Base pay range: $158,401 - $179,521 per year
Generous equity options offering
Corporate bonus program
Industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.)