Executive Director, Global Program Lead, Oncology (Pumitamig)

Bristol Myers Squibb•Princeton, NJ

2d•Onsite

About The Position

Bristol Myers Squibb (BMS) is seeking an Executive Director, Global Program Leader (GPL) for Pumitamig, a PD-L1xVEGFF bispecific antibody in development for solid tumors in collaboration with BioNTech. This role is within the Hematology, Oncology & Cell Therapy (HOCT) Global Program Leadership organization. GPLs are strategic, problem-solving scientific leaders responsible for driving the development and commercialization of innovative medicines. They act as the primary point of accountability for their assigned assets, leading multi-disciplinary teams to develop and implement integrated asset strategies. The goal is to achieve ambitious portfolio objectives, ensuring only high-quality, differentiated assets reach the market.

Requirements

MD, PhD, DVM, PharmD, MBA or equivalent advanced degree of relevance, with experience in the drug development process.
10+ years of experience in the drug development process and leadership experience in academic or industry setting, including education where applicable.
Expertise in the drug development process with in-depth know-how and experience in matrix team leadership, relevant regulatory expectations, and overall drug development and commercialization.
Successful track record of leading through influence and working across complex, global organizational matrix.
Significant experience in oncology, specifically lung preferred, with demonstrated understanding of the role of basic biology, pharmaceutical optimization, translational medicine, and clinical pharmacology, including exposure-response relationships and dose selection.
Strong understanding of relevant regulatory health authority expectations and regulations for drug development and impact on commercialization.
Working knowledge of all functional areas of exploratory development, including chemistry/biochemistry, biology, toxicology, CMC, translational medicine, early clinical development, etc.
Demonstrated scientific acumen and mechanistic understanding of pharmacology and disease biology.
Ability to create a clear purpose, global vision, strategies and key priorities for competing successfully in the evolving pharmaceutical and health care industry.
Demonstrated ability to lead cross-functional team to execute Development Plans which have global perspective and focus on product differentiation, including opportunities for data driven acceleration.
Demonstrated ability to objectively assess complex but relatively sparse data sets, make informed decisions and take action in the face of uncertainty.
Demonstrated ability to present complex programs to senior leaders and influence decision making.
Experience in successfully managing and leading high performing, cross-functional matrix teams or complex multi-functional organizations.
Demonstrated ability to coach and mentor others to enhance performance and/or facilitate career progression.
Ability to effectively and seamlessly multi-task, and prioritize across multiple development assets, with complex strategies and accelerated development timelines.
Demonstrated ability to successfully and effectively cooperate, collaborate and work across functions.
Demonstrated ability to advise and participate in business development due-diligence evaluations and transaction recommendations.

Nice To Haves

Experience in lung oncology
Experience in cell therapy

Responsibilities

Create a vision and define the strategy and integrated development plan for each asset within their portfolio.
Develop objective criteria for evaluating assets advancing through the pipeline to enable robust debate and rapid, data-driven decision making.
Ensure high-quality and differentiated assets enter the market.
Design and execute effective development programs in support of overall R&D portfolio goals, utilizing an understanding of disease biology, the drug development process, and late-stage challenges.
Engage cross-company expertise and utilize advisory groups and governance bodies to define, revise, and champion asset development strategies and implementation plans.
Continuously analyze progress, engage in critical thinking, and apply strong problem-solving skills to deliver key data and interpretations for decision making.
Ensure team processes and outputs meet established program standards (e.g., within budget, on schedule, compliant), while seeking opportunities for streamlining and continuous improvement.
Engage senior leaders and functional stakeholders to ensure alignment of program strategy and operational plans with functional capabilities.
Clearly communicate program risks, implications of competitive landscape changes, and progress toward key milestones.
Provide input to and drive portfolio-level strategy for internal and external opportunities.
Participate in regulatory filings (NDA, BLA) and develop strategies for orphan drug designation.
Engage with Health Authorities and/or Advisory Committees in the design of clinical trials and endpoints.
Lead teams to develop program strategy, clinical program plans, commercialization strategy plans, and business cases, understanding how access, pricing, and reimbursement needs inform trial design.
Build and maintain collaborative relationships with external stakeholders (Opinion Leaders, Strategic Alliance Partners, Patient Advocacy Leaders, Health Authorities) and incorporate their insights.
Understand clinical trial operational complexities from study start-up through readout.
Take an active role in the analysis and/or interpretation of clinical data and its translation into scientific communication and commercial strategy.
Integrate commercialization inputs and deliverables to design late-stage program strategy that enables approval of a meaningfully differentiated asset with potential to maximize value.
Understand necessary commercial inputs to inform the end-to-end development process leading to regulatory approval and successful commercialization.
Integrate market inputs into the integrated development plan, including clinical plans and labeling strategy.
Contribute to the development of forecasts and investment scenarios, risk assessment, valuations, and decision-making implications.
Contribute to the development of brand hallmarks and brand strategy, understanding their relationship to clinical trial design.
Support the development of KOL plans and engagements, and leverage KOL input in context of development programs and evidence communication.
Support commercial needs and recommendations to guide CMC and GPS on trade packaging and commercial product.
Collaborate effectively with matrix functions by building trust and driving toward the collective success of the program.
Gather diverse perspectives, assess alternate resolutions, and make thoughtful, informed Enterprise decisions.
Build, lead, and inspire high-performing cross-functional matrix teams through a unified program strategy.
Take initiative to address challenges, remove barriers, and hold others accountable for collective success.
Lead with integrity, self-awareness, humility, and seek feedback.

Benefits

Medical, pharmacy, dental, and vision care
BMS Well-Being Account
BMS Living Life Better
Employee Assistance Programs (EAP)
401(k) plan
Short- and long-term disability
Life insurance
Accident insurance
Supplemental health insurance
Business travel protection
Personal liability protection
Identity theft benefit
Legal support
Survivor support
Flexible time off (unlimited, with manager approval)
11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
160 hours annual paid vacation for new hires (Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees)
3 optional holidays
Unlimited paid sick time
Up to 2 paid volunteer days per year
Summer hours flexibility
Leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs
Annual Global Shutdown between Christmas and New Years Day