Executive Director, Global Program Lead, Oncology (Pumitamig)

Bristol Myers Squibb • Princeton, NJ

8d • Onsite

About The Position

Bristol Myers Squibb (BMS) is seeking an Executive Director, Global Program Leader (GPL) for Pumitamig, a PD-L1xVEGFF bispecific antibody in development for solid tumors in collaboration with BioNTech. This role is within the Hematology, Oncology & Cell Therapy (HOCT) Global Program Leadership organization. GPLs are strategic, problem-solving scientific leaders responsible for driving the development and commercialization of innovative medicines. They act as the primary point of accountability for their assigned assets, leading multi-disciplinary teams to develop and implement integrated asset strategies. The GPL is responsible for creating a vision and strategy, defining objective evaluation criteria for assets, and ensuring high-quality, differentiated assets reach the market.

Requirements

• MD, PhD, DVM, PharmD, MBA or equivalent advanced degree of relevance, with experience in the drug development process.
• 10+ years of experience in the drug development process and leadership experience in an academic or industry setting, including education where applicable.
• Expertise in the drug development process with in-depth know-how and experience in matrix team leadership, relevant regulatory expectations, and overall drug development and commercialization.
• Successful track record of leading through influence and working across complex, global organizational matrix.
• Significant experience in oncology, specifically lung preferred, with demonstrated understanding of the role of basic biology, pharmaceutical optimization, translational medicine, and clinical pharmacology, including exposure-response relationships and dose selection.
• Strong understanding of relevant regulatory health authority expectations and regulations for drug development and impact on commercialization.
• Working knowledge of all functional areas of exploratory development, including chemistry/biochemistry, biology, toxicology, CMC, translational medicine, early clinical development, etc.
• Demonstrated scientific acumen and mechanistic understanding of pharmacology and disease biology.
• Ability to create a clear purpose, global vision, strategies, and key priorities for competing successfully in the evolving pharmaceutical and health care industry.
• Demonstrated ability to lead cross-functional teams to execute Development Plans with a global perspective and focus on product differentiation, including opportunities for data-driven acceleration.
• Demonstrated ability to objectively assess complex but relatively sparse data sets, make informed decisions, and take action in the face of uncertainty.
• Demonstrated ability to present complex programs to senior leaders and influence decision making.
• Experience in successfully managing and leading high-performing, cross-functional matrix teams or complex multi-functional organizations.
• Demonstrated ability to coach and mentor others to enhance performance and/or facilitate career progression.
• Ability to effectively and seamlessly multi-task and prioritize across multiple development assets with complex strategies and accelerated development timelines.
• Demonstrated ability to successfully and effectively cooperate, collaborate, and work across functions.
• Demonstrated ability to advise and participate in business development due diligence evaluations and transaction recommendations.

Nice To Haves

• Experience in lung cancer.
• Experience with PD-L1xVEGFF bispecific antibodies.

Responsibilities

• Create a vision and define the strategy and integrated development plan for each asset within their portfolio.
• Develop objective criteria for evaluating assets advancing through the pipeline to enable robust debate and rapid, data-driven decision making.
• Ensure only high-quality and differentiated assets enter the market.
• Design and execute effective development programs in support of overall R&D portfolio goals, utilizing an understanding of disease biology, the drug development process, and late-stage challenges.
• Engage cross-company expertise and utilize advisory groups and governance bodies to define, revise, and champion asset development strategies and implementation plans.
• Continuously analyze progress, engage in critical thinking, and assert strong problem-solving to deliver key data and interpretation for decision making.
• Deliver high-quality assets to commercialization with the potential for a competitive profile, addressing unmet medical needs and providing favorable shareholder return.
• Ensure the process and output of the team meet established program standards (e.g., within budget, on schedule, compliant) and identify opportunities for streamlining development without compromising quality.
• Engage senior leaders and functional area stakeholders to ensure alignment of program strategy and operational plans with functional area capabilities.
• Clearly communicate program risks, implications of changes in the competitive landscape, and progress toward key milestones.
• Provide input to and drive portfolio-level strategy for both internal and external opportunities.
• Participate in regulatory filings (NDA, BLA) and develop strategy for orphan drug designation.
• Engage with Health Authorities and/or Advisory Committees in the design of clinical trials and endpoints.
• Lead teams to develop program strategy, clinical program, commercialization strategy plans, and business case development.
• Understand how access, pricing, and reimbursement needs inform trial design and support the value proposition.
• Build and maintain collaborative relationships with external stakeholders (Opinion Leaders, Strategic Alliance Partners, Patient Advocacy Leaders, Health Authorities) and incorporate their insights.
• Understand clinical trial operational complexities from study start-up through readout.
• Take an active role in the analysis and/or interpretation of clinical data and its translation into scientific communication and commercial strategy.
• Understand and reflect the impact of VAP inputs (Early Access Review and DEX recommendations, commercial opportunity assessment, TOP / TPP requirements, and value drivers) in clinical trial design.
• Actively support Investor Relations and Public Affairs in managing external BMS communications.
• Integrate commercialization inputs and deliverables to design late-stage program strategy for approval of a meaningfully differentiated asset with potential to maximize asset value.
• Understand necessary commercial inputs for the end-to-end development process leading to regulatory approval and successful commercialization.
• Integrate market inputs (e.g., TPP, DEX/VAP, CI insights) into the integrated development plan, including clinical plans and labeling strategy.
• Appreciate the translation of clinical data into claims and considerations for label development.
• Contribute to the development of forecasts and investment scenarios, risk assessment, valuations, and decision-making implications.
• Contribute to the development of brand hallmarks and brand strategy, understanding their relationship to clinical trial design.
• In partnership with Medical Affairs, support the development of KOL plans and engagements, and leverage KOL input in the context of development programs and evidence communication.
• Support commercial needs and recommendations to guide CMC and GPS on trade packaging and commercial product.
• Inclusively collaborate across the BMS matrix with an enterprise mindset, building trust and driving toward collective program success.
• Demonstrate enterprise mindset problem-solving and decision making by gathering diverse perspectives, assessing alternate resolutions, and making thoughtful, informed decisions.
• Develop and lead high-performing cross-functional matrix teams through a unified program strategy for patients.
• Take initiative to address challenges, remove barriers, and hold others accountable for collective success of program outcomes and team collaboration.
• Lead with integrity, self-awareness, humility, and seek feedback.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees))
• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Executive