Executive Director, Biometrics – CVRM

AstraZeneca•Cambridge, MA

7d•$278,568 - $417,852•Hybrid

About The Position

The Executive Director, Biometrics – CVRM is a senior leadership role within the CVRM Development organization and a core member of the relevant CVRM leadership team. This position leads the biometrics strategy across a disease area franchise, providing scientific and strategic direction for Biometrics. The role is accountable for ensuring that robust, innovative, and decision-relevant evidence is generated throughout the development lifecycle. The Executive Director will influence portfolio decisions, strengthen regulatory strategies, enable efficient delivery, and build a high-performing biometrics organization equipped for the future, working across a global matrix.

Requirements

MSc in Biostatistics, Statistics, Applied Mathematics, or another relevant quantitative discipline.
Extensive experience in the pharmaceutical, biotechnology, or life sciences industry, with a strong understanding of the end-to-end drug development lifecycle in cardiovascular, renal, metabolic, or related disease areas.
Demonstrated expertise across multiple clinical development phases, ideally including large, complex, and pivotal Phase III programs.
Significant experience leading statistical and programming contribution across multiple clinical development programs in a global, matrixed organization.
Strong understanding of statistical principles and regulatory expectations relevant to clinical trials, including estimates, multiplicity, missing data, interim analyses, and adaptive designs.
Experience leading organizational change, capability building, productivity initiatives, or digital transformation.
A strong external scientific network and evidence of contribution to professional, academic, or cross-industry groups.
Excellent written, verbal, and presentation skills, with the confidence to engage senior leaders, governance bodies, regulators, and external experts.

Nice To Haves

Experience leading enterprise-wide or cross-Therapy Area initiatives involving AI, automation, operating-model transformation, or productivity improvement.
PhD in Biostatistics, Statistics, Applied Mathematics, or another relevant quantitative discipline.
Experience applying or evaluating AI-enabled, machine-learning, or generative AI approaches in clinical development, data analysis, or scientific operations.
Understanding of data integrity, clinical data standards, and regulatory expectations, including CDISC standards.
Experience with real-world evidence, digital health technologies, patient-generated data, or novel clinical outcome assessments.
Experience with portfolio strategy, business development, due diligence, or in-licensing activities.
Experience developing externalization models and managing strategic outsourcing collaborations.

Responsibilities

Lead and develop a global statistics organization comprising individual contributors and people leaders within a matrix environment.
Establish a clear vision, priorities, and operating model aligned with the CVRM development strategy.
Ensure that clinical development programs use appropriate statistical designs, data sources, analytical methods, tools, and processes to address their objectives clearly and robustly.
Provide oversight for the quality and timeliness of Biometrics contributions to clinical development planning, study design, protocols, statistical analysis plans, clinical study reports, regulatory submissions, and responses to health authorities.
Ensure that decision-makers understand both the expected value and the uncertainty associated with development and investment choices.
Work with CVRM and enterprise partners to identify and deliver measurable improvements in productivity, quality, and speed.
Support the responsible adoption of AI-enabled and generative AI tools for activities such as data analysis, statistical programming, document creation, submission preparation, and knowledge retrieval.