Engineer II, Upstream Development for Protein Development and Manufacturing (Contract)

Vaxcyte • San Carlos, CA

11d • $70 - $78 • Onsite

About The Position

Vaxcyte is seeking a talented and experienced Engineer II, to join the Upstream Process Development group within the Protein Development and CMC team. This is an exciting opportunity to join an outstanding team pursuing bacterial fermentation development at Vaxcyte. The successful candidate will have hands-on experience operating and maintaining bioreactors, including Ambr® 250, at laboratory scale. Experience with pilot scale fermentation and recovery equipment is a plus. The candidate will be skillful in analyzing and presenting data for process improvements, troubleshooting, and optimization. They will be an exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals, possessing strong organizational and planning skills.

Requirements

• BS in Chemical Engineering or a related discipline with 10+ years, MS with 7+ years, or PhD with 2-5 years of relevant Pharma/Biotech industry experience.
• Hands-on experience with fermentation and/or primary recovery unit operations.
• Good understanding in fundamentals of bioreactor design, operation and controls.
• Strong knowledge of aseptic techniques
• Understanding of fermentation scale up and development of scale down models
• Familiarity with DoE (Design of Experiments) principles and software.
• Familiarity with regulatory requirements of biotherapeutics.

Nice To Haves

• Experience with pilot scale fermentation and recovery equipment.
• Mechanical and technical knowledge of primary recovery unit operations such as homogenization, centrifugation, and depth filtration.
• Late-stage process characterization experience.

Responsibilities

• Lead operational activities related to bioreactor set-up, monitoring, harvest, and maintenance.
• Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls.
• Provide engineering support for design, implementation, and qualification of scale-down models.
• Author SOPs (standard operating procedure), process flow diagrams and batch records.
• Analyze and present fermentation data at internal project meetings.
• Participate in upstream database management and documentation in electronic notebooks.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level