Engineer II, CMC Development Operations
About The Position
The Operations Science and Technology team is seeking a highly skilled and motivated Engineer II to support pilot-scale nucleic acid and formulated nucleic acid product operations. This role is responsible for transferring processes from bench to pilot scale and generating DNA/RNA/LNP/DP for developmental and tox studiers, enabling first-time filings and commercial updates. This is an onsite role based in Moderna’s Technology Center campus in Norwood, MA. In this role, you will execute independently while partnering cross-functionally to implement robust, scalable processes. You will take increasing ownership of technical projects, contribute to technology transfer activities, and proactively identify and resolve process challenges in a fast-paced environment.
Requirements
- Bachelor’s or Master’s degree in Life Sciences, Chemistry, Engineering, Pharmaceutical Sciences, or related/relevant technical discipline
- 2 years of relevant experience with a Bachelor’s degree or minimal experience with a Master’s degree.
Nice To Haves
- Advanced degree in Life Sciences, Chemistry, Engineering, Data Science, or a related technical discipline preferred.
- 2 to 3 years of relevant experience with a Master’s degree, or 3 to 5 years of relevant experience with a Bachelor’s degree preferred.
- Hands-on experience in process development or operations, including one or more: enzymatic reactions, chromatography, tangential flow filtration, formulation of biologics
- Demonstrated ability to execute and troubleshoot processes independently in a fast-paced environment
- Strong communication skills with the ability to collaborate effectively across cross-functional teams
- Experience with mRNA/DNA synthesis, LNP formulation, and/or drug product processes
- Experience in technology transfer and scale-up of processes
- Demonstrated ability to own and drive technical projects or workstreams
- Ability to analyze complex datasets and translate findings into actionable improvements
- Proven ability to expand technical skillset and operate across multiple process areas
Responsibilities
- Lead or contribute to technical projects with increasing ownership related to DNA/RNA/LNP/DP processes, including technology transfer, process optimization, and continuous improvement initiatives
- Serve as a batch lead supporting execution, propose troubleshooting in real time to ensure successful outcomes
- Propose and implement solutions to technical challenges, gaps, and process deviations
- Collaborate cross-functionally with Process Development, Analytical, and other teams to support tech transfer and process robustness
- Distill and communicate batch-related data to inform process improvements and decision-making
- Author and optimize technical documentation, including SOPs and protocols, and support training of team members
- Provide operational leadership during batches, guide junior team members, and align stakeholders on project goals
- Apply operational excellence principles to improve workflows, lab organization, and execution efficiency
- Identify and mitigate risks, including safety, process, and operational risks; escalate when appropriate
- Maintain compliance with GDP practices, safety procedures, and environmental regulations
Benefits
- Competitive healthcare, plus voluntary benefit programs to support your unique needs
- A holistic approach to well-being, with access to fitness, mindfulness, and mental health support
- Family planning benefits, including fertility, adoption, and surrogacy support
- Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown
- Savings and investments to help you plan for the future
- Location-specific perks and extras
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
