Downstream Engineer III

Takeda•Lexington, MA

1d•Onsite

About The Position

Join Takeda as a Downstream Process Development, Engineer III. As a solid professional, you receive assignments with objectives and goals, providing guidance to employees based on established policies. Your work is reviewed by management to assess goal achievement and adherence to policies, with opportunities to recommend policy changes within your unit or sub-unit. You address moderate scope problems, applying judgment within defined procedures and policies, and act as an advisor when needed. Your role involves frequent use of industry practices and general knowledge, ensuring project completion on schedule, primarily liaising internally with subordinates and supervisors, with minimal external contacts and guidance. The Downstream Process Development Engineer III is responsible for supporting downstream biotherapeutics process development through hands-on purification and recovery experiments. In this individual contributor role, you will support process development across multiple scales, from micro scale through bench and pilot scale, and contribute to both early-stage and late-stage programs. You will work with more senior process engineers to plan and execute larger experiments, while also partnering with process development team members to generate data, maintain accurate records, and contribute to the development and optimization of downstream processes. As an Engineer III in downstream process development, you will contribute independently within established procedures, use sound judgment in routine problem solving, and support project delivery on schedule.

Requirements

Bachelor's degree with 2 or more years of relevant experience, or master’s degree with relevant experience, in chemical engineering, chemistry, biochemistry, biotechnology, or a related field
Experience with chromatography, harvest, ultrafiltration and diafiltration, and viral clearance steps
Some relevant experience in process development, protein purification, or a related laboratory setting
Experience with basic bioprocess control systems
Experience using electronic laboratory notebooks for study documentation and data entry
Ability to perform basic data analysis and present results clearly in written form
Familiarity with technical writing for laboratory reports or development documents
Understanding of laboratory practices, process development methods, and quality requirements
Ability to follow detailed procedures, maintain accurate records, and work under close supervision
Comfort with emerging digital tools and openness to artificial intelligence-enabled processes that support data analysis, documentation, and workflow improvement

Responsibilities

Execute chromatography, harvest operations, ultrafiltration and diafiltration, and viral clearance experiments, with additional potential support of bioconjugation
Support downstream process development across micro scale, bench scale, and pilot scale studies
Maintain laboratory equipment and support routine readiness of instruments used in process development work
Work with more senior process engineers to plan and execute larger experiments and study activities
Document experimental work in electronic laboratory notebooks and maintain clear, complete, and timely records
Perform basic data analysis to review trends, compare conditions, and support study conclusions
Prepare technical summaries, study updates, and other written materials to share results and findings
Follow established laboratory and process development procedures, including quality and safety requirements
Contribute to continuous improvement efforts by identifying ways to improve workflows, data capture, and experimental execution
Assist with small projects or specific project tasks under close supervision
Apply judgment within defined procedures and policies to address moderate scope problems and support timely project completion
Serve as a reliable advisor to peers and junior team members when needed, while keeping work aligned with team goals and manager guidance