Downstream Development Associate II
About The Position
Do you want to join a team where the mission is meaningful, the challenges are complex, and you can directly see the results of your hard work? Lundbeck Seattle BioPharmaceuticals (Lu-SBP), located in Bothell, Washington, is the Process Development Center of Excellence for Biologics within the global Lundbeck CMC organization. Since integrating into Lundbeck in October 2019, Lu-SBP has supported commercial launch of Lundbeck’s first biologic product (Vyepti) and advancement of a growing biologics pipeline in collaboration with our Copenhagen-based Process Science & Validation Team. The Lu-SBP team leads and supports the development of new product candidates from cell line development through commercial validation of Drug Substance and Drug Product manufacturing processes. Join us on our journey to advance brain health and transform lives. Summary: Performs downstream process development experiments and supporting activities, which enable both early and late-stage manufacturing process design for therapeutic monoclonal antibody production via yeast and mammalian expression systems.
Requirements
- Accredited bachelor's degree and a minimum of 2+ years of biotechnology/pharmaceutical industry experience or equivalent combination of education and experience totaling 4 years.
- Basic understanding of the principles of liquid chromatography, membrane filtration, sedimentation/centrifugation, aqueous physical chemistry, and protein chemistry.
- Familiar with basic laboratory equipment, including pH, conductivity, & temperature meters, pumps, pressure gauges, weight scales, pipette dispensers, and tabletop centrifuges.
- Excellent verbal communication skills to interact collaboratively with Process Development teammates.
- Well-developed organizational skills and the ability to take a proactive approach to job responsibilities.
- Ability to comply with FDA GMP documentation regulations and industry standard safety practices.
- Proficiency in Microsoft Windows 10/Office.
- Must be able to lift to 30 pounds on occasion.
Nice To Haves
- An accredited B.S. degree in science or engineering (i.e. Biochemical Engineering, Chemical Engineering, Biotechnology Engineering, Biochemistry, Biotechnology or equivalent).
- Experience with analytical techniques such as HPLC, UPLC, and/or CE a plus.
- Experience with pilot scale operations a plus.
- Experience with MPLC systems such as the Äkta/Unicorn platform a plus.
Responsibilities
- Performs small-scale downstream process development experiments for monoclonal antibodies, as applied to liquid chromatography and tangential/normal flow filtration.
- Prepares experimental intermediate samples for further analytical testing, including purification via miniature liquid chromatography and ultrafiltration devices.
- Prepares purified protein product to support upstream process development and supply further downstream process development activities.
- Performs analytical methods, such as UV-visible spectrophotometry, turbidimetry, density measurement, size exclusion and protein A affinity HPLC, and biolayer interferometry.
- Organizes and analyzes primary data and prepares concise presentations and reports.
Benefits
- flexible paid time off (PTO)
- health benefits to include Medical, Dental and Vision
- company match 401k
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Mid Level
