Distinguished Scientist, Quantitative Biosciences/ Nonclinical Pharmacology

Merck • Boston, MA

2d • $231,900 - $365,000 • Hybrid

About The Position

We are committed to improving the health and well-being of people around the world. As a leading global pharmaceutical company, we strive to make a difference through innovative research, discovery, and development of life-saving medications and vaccines. With over a century of experience and a steadfast dedication to scientific excellence, we have become a trusted name in the industry. Join our team and be a part of our mission to create a healthier future for all.
We have an exciting opportunity for a Distinguished Scientist with deep experience spanning drug discovery, nonclinical pharmacology, and broader pharmaceutical Research and Development (R&D) to join our Quantitative Biosciences (QB) leadership team. Reporting to the Vice President and Global Head of QB, and partnering closely with discovery scientists across our global Discovery, Preclinical, & Translational Medicine (DPTM) organization, you will leverage your expertise in pharmacology, disease biology, and drug discovery to shape QB and network-wide strategy, guide project teams, and drive cross-functional collaboration. You will lead opportunity assessments and help advance therapeutic programs across broad disease areas and modalities (small molecules, biologics, and vaccines).
In this role, you will serve as a central scientific integrator for mechanistic pharmacology and translation within QB, ensuring pharmacology strategies directly enable SAR progression, differentiate mechanisms of action, and support confident translation into early clinical development.
If you thrive at the intersection of deep quantitative thinking, translational research, and enterprise influence—and are passionate about developing others and elevating decision quality across a global R&D organization—we invite you to join our purpose-driven team.

Requirements

• Bachelor’s degree in pharmacology, biology, or a related discipline, with deep expertise in mechanistic pharmacology, drug discovery, and preclinical development across modalities (small molecules, biologics, vaccines)
• 15+ years of proven leadership in a biopharmaceutical setting, with extensive research experience and a demonstrated impact on drug discovery and translational programs.
• Experience in cardiometabolic disease, obesity, oncology, and/or immunology strongly preferred, with a track record reflected in publications and scientific reputation.
• Deep expertise across pharmacology disciplines, including biochemical/biophysical, cellular, and in vivo pharmacology, PK/PD, IVIVC, and translational science.
• Proven ability to simplify complex scientific challenges into clear, actionable strategies, and to influence without authority across organizational boundaries to drive alignment, consistency, and high-quality decision-making.
• Strong executive communication and stakeholder engagement skills, with the ability to effectively partner with senior leaders, cross-functional teams, and external collaborators.
• Demonstrated experience in business development and licensing, including competitive landscape assessment, industry analysis, and scientific support for transactions and due diligence.
• Track record of mentoring and developing scientists across disciplines, elevating organizational capability beyond immediate teams.
• Experience in portfolio strategy and management, including dashboarding, data visualization, and resource planning.
• Ability to operate with agility in a dynamic environment, adapting to evolving priorities while maintaining strategic focus.
• A passion for scientific innovation, problem-solving, and developing others, coupled with strong written and verbal communication skills.
• Coaching
• Cross-Functional Teamwork
• Drug Development
• Executive Presence
• Influence
• Mentorship
• Pharmacology
• Research Leadership
• Strategic

Nice To Haves

• Advanced degree (Ph.D.) preferred
• Biologics
• Early Clinical Development
• High-Throughput Screening
• Leading Project Teams
• Translational Research

Responsibilities

• Serve as a scientific integrator, strategic partner, and chief-of-staff to the Vice President/ Global Department Head of Quantitative Biosciences and on the QB leadership team, shaping enterprise pharmacology & translational strategy in alignment with QB and DPTM priorities.
• Drive clarity and alignment on pharmacology strategies that enable efficient SAR progression and translational confidence—ensuring approaches are fit-for-purpose, decision-focused, and avoid unnecessary complexity.
• Apply deep expertise in biochemical, cellular, and translational systems to: Clarify mechanism-of-action & inform molecule differentiation at critical decision points
• Guide fit-for-purpose assay and model strategies that streamline research operating plans (ROPs), and directly inform SAR and program progression
• Advise and mentor broadly across QB and DPTM, guiding scientists and multidisciplinary teams in assay selection/design/execution, mechanistic pharmacology, and translational science to accelerate programs, elevate rigor, and develop talent.
• Act as a trusted advisor on high-impact and complex programs, helping teams resolve key scientific uncertainties and translating complex data into clear, actionable insights that inform strategic and program-level decisions.
• Shape the QB pharmacology portfolio and resourcing strategy, contributing to early target and end-to-end nonclinical pharmacology planning across disease areas and modalities, and driving visibility through portfolio dashboards, resource planning, and stakeholder alignment.
• Assess and interpret the evolving external landscape, delivering actionable insights on competitive pipelines, emerging trends, and strategic opportunities through dashboards, analyses, and executive-ready recommendations.
• Partner closely with Business Development & Licensing (BD&L) as a scientific leader in pharmacology and quantitative biosciences, supporting asset evaluations, due diligence, and opportunity assessments across modalities and stages of R&D.
• Foster a culture of scientific rigor, critical thinking, and open dialogue, strengthening decision-making and elevating organizational capability.
• Promote a collaborative, inclusive, and high-performing environment aligned with company values and mission.

Benefits

• medical, dental, vision healthcare and other insurance benefits (for employee and family)
• retirement benefits, including 401(k)
• paid holidays
• vacation
• compassionate and sick days
• annual bonus
• long-term incentive

What This Job Offers

• Job Type: Full-time
• Career Level: Senior