Discovery Project Manager — Cell Therapy Discovery

AstraZenecaCambridge, MA
$137,938 - $206,906Hybrid

About The Position

Are you ready to co-own the execution of next-generation cell therapy programs and help transform groundbreaking science into meaningful outcomes for patients? As a Discovery Project Manager within Cell Therapy Discovery, you will play a critical role in driving discovery-stage programs focused on autoimmune and immune-mediated diseases. Working in partnership with Bioscience Leads, you will provide strategic project leadership across a portfolio that spans from pre-Target Selection Investment Decision through preclinical proof of concept and transition into Global Product Teams. Our portfolio includes LVV-based CAR-T, LNP, autologous, and allogeneic cell therapy approaches. This role operates within a unique partnership model where scientific leadership and project leadership work hand-in-hand to ensure clear decision-making, effective execution, and timely delivery of program objectives. Within a highly collaborative and agile environment, you will help shape how discovery projects are managed while contributing directly to programs advancing toward the clinic.

Requirements

  • Bachelor's degree with a minimum of 10 year's experience.
  • Significant project management experience within pharmaceutical, biotechnology, drug discovery, or early development environments.
  • Strong understanding of autoimmune and immune-mediated disease biology and drug development.
  • Demonstrated success managing complex, cross-functional projects through key development milestones and investment decisions.
  • Experience partnering directly with scientific leaders to drive project execution and delivery.
  • Strong stakeholder management, communication, and influencing skills.
  • Ability to challenge constructively, navigate ambiguity, and facilitate effective decision-making.
  • Experience utilizing project management methodologies, planning tools, and governance frameworks.

Nice To Haves

  • Advanced degree (PhD, MSc, MBA, or equivalent).
  • Experience supporting cell therapy discovery programs, including CAR-T, LNP, autologous, and allogeneic approaches.
  • Experience preparing for major governance and investment decision milestones.
  • Experience coordinating project transfers across global teams and regions.
  • Knowledge of portfolio management systems such as PLANIT or equivalent platforms.
  • Experience applying AI-enabled tools to project planning, risk assessment, or reporting activities.

Responsibilities

  • Partner closely with Bioscience Leads to drive execution, delivery, and decision-making across discovery-stage programs.
  • Co-own program scope, timelines, budgets, risks, and milestones.
  • Facilitate cross-functional collaboration and alignment to ensure successful project delivery.
  • Challenge assumptions, drive accountability, and proactively address barriers to progress.
  • Lead project initiation activities including project charters, RACI development, governance structures, and team operating models.
  • Develop and maintain integrated project plans and schedules.
  • Identify project risks and opportunities early and coordinate appropriate mitigation activities.
  • Lead and facilitate project team meetings and product development reviews.
  • Manage project interdependencies, scope adjustments, and escalation pathways.
  • Maintain project plans and governance documentation, ensuring alignment with organizational processes.
  • Prepare project updates, dashboards, and milestone reporting for leadership teams.
  • Leverage AI-enabled solutions to enhance project scheduling, risk analysis, reporting, and decision support.
  • Promote responsible and effective use of AI tools across project teams.
  • Stay current with emerging technologies that improve project execution and operational efficiency.
  • Partner effectively with scientific, technical, and business stakeholders.
  • Support governance reviews and investment decision activities.
  • Drive clear communication and alignment across global cross-functional teams.
  • Lead the successful transition of programs to Global Product Teams and incoming Global Project Managers.
  • Ensure readiness of deliverables, data packages, and handover documentation.
  • Capture and apply lessons learned to continuously improve project execution practices.
  • Coordinate project handovers with regional teams, including partnerships supporting China Discovery and investigator-initiated trial preparations.

Benefits

  • Qualified retirement programs
  • Paid time off (i.e., vacation, holiday, and leaves)
  • Health coverage
  • Dental coverage
  • Vision coverage
  • Opportunity to receive short-term incentive bonuses
  • Equity-based awards for salaried roles
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