Discovery ADME Project Leader (Radioligand Therapeutics)
About The Position
We are seeking an experienced, accomplished drug hunter as a Discovery ADME Project Leader focused on Radioligand Therapeutics (Radioconjugates). The ideal candidate will provide deep mechanistic understanding of drug disposition, PK, and translational science, plus the ability to integrate biology, chemistry, and modeling. Experience with Small Molecule Discovery and in project teams with Beyond-Rule-of-Five and pan-modality chemotypes is advantageous. The successful candidate will bring exceptional scientific depth, acumen, and leadership as an integral member of the project team to create bold Target Product Profiles, help establish molecule design strategy, expectations, Research Operating Plans, and partner globally, cross-functionally, and ensure teams are advancing The Right Molecule to The Right Study at The Right Time (our three R’s).
Requirements
- PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical or Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.
- 3+ years of post-graduation industry experience in a Radioligand Therapeutics (Radioconjugates) drug discovery environment, driving discovery teams and you understand how an ADME Project Leader impacts the life cycle/flywheel (Design, Make, Test, Analyze) of a discovery project.
- Exceptional written and verbal communication skills; ability to successfully navigate ambiguity and/or global cross-functional collaborations.
- Demonstrated ability to translate complex technical concepts into strategic value for senior leadership and cross-functional partners.
Nice To Haves
- Subject matter ADME expertise and a working knowledge of medicinal chemistry, and Toxicology principles is advantageous.
- Experience with Small Molecule Discovery and in project teams with Beyond-Rule-of-Five and pan-modality chemotypes is advantageous.
Responsibilities
- Keep Safety as a priority.
- Develop and execute integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses being tested, and regulatory expectations.
- As a Radioligand Therapeutics (bioconjugates) ADME Project Leader, bring integrated ADME subject matter expertise, driving holistic ADME strategy by aligning pharmacokinetics, metabolism, and mechanistic disposition data with early safety signals; interpret exposure–toxicity relationships, therapeutic index, and off-target liabilities to proactively de-risk programs and enable data-driven candidate selection decisions.
- Integrate ADME, pharmacology, and toxicology to enable translational simulations and modeling to support dose selection, design of PK/PD, efficacy and safety studies.
- Define stage-, modality-, and issue-appropriate screening, decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design and optimization through data-driven design principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as the ADME strategy and science single-point-of-accountability on cross-functional program teams, translating ADME findings into actional design and test hypotheses.
- Collaborate closely with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery Functions to drive high quality candidate selections.
- Contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
- Represent ADME in portfolio governance discussions and leadership reviews.
- Implement best practices, assay innovation, and automation where appropriate.
- Drive continuous improvement in data reporting, knowledge management, and decision frameworks.
- Seek and leverage AI and agentic tools where possible to pipeline data, interpret data and share results.
- Maintain inspection-ready documentation and alignment with regulatory expectations.
- Mentor, teach and grow junior scientists and contribute to functional capability building.
Benefits
- company bonus (depending, in part, on company and individual performance)
- company-sponsored 401(k)
- pension
- vacation benefits
- eligibility for medical, dental, vision and prescription drug benefits
- flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
- life insurance and death benefits
- certain time off and leave of absence benefits
- well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
