Director, US Forecasting & Analytics– Vaccines & Immune Therapies

AstraZeneca•Wilmington, DE

3d•Hybrid

About The Position

The Director, US Forecasting & Analytics – Vaccines & Immune Therapies (V&I) is a senior commercial insights leader responsible for US demand forecasting and analytics across the V&I portfolio. The role is predominantly forecast-focused, serving as the US forecasting lead and strategic thought partner to Marketing, Finance, Market Access, and US teams. The role also includes people leadership, vendor management, and forecasting-adjacent analytics leadership to ensure the effective deployment of analytical resources and continuous evolution of forecasting and insight capabilities within V&I. Time allocation may vary by business cycle and portfolio priorities. This position plays a critical role in shaping commercial expectations, risk and opportunity framing, and executive decision-making for in-market and late-stage pipeline vaccines and immune therapies.

Requirements

Bachelor’s degree in a quantitative, scientific, or business-related field required (e.g., Statistics, Economics, Mathematics, Engineering, Computer/Data Science).
8+ years’ experience in US pharmaceutical commercial forecasting, including in-market and late-stage pipeline assets
Hands-on model ownership experience (build, refresh, and performance tracking) across short- and long-term horizons
Expertise in scenario-based forecasting, sensitivity analysis, and driver-based narratives to support senior decision-making
Strong capability integrating multiple data types (e.g., IQVIA, claims, epidemiology, RWD/RWE, primary research) into coherent, decision-grade forecasts
Working knowledge of advanced analytics/ML approaches (e.g., time series, causal inference, ensembles) and where they add value vs. traditional methods
Fluency in modern analytics tooling and automation (e.g., Python/R/SQL, BI/visualization), with ability to partner effectively with data engineering and analytics teams
Demonstrated forecast governance and model risk discipline (traceable assumptions, documentation, and clear explanations)
Strong understanding of US market access and payer dynamics and how they impact demand (coverage, contracting, channel, policy)
Exceptional communication: translates complex analysis into clear, executive-ready insights, options, and recommendations
Strong commercial competence across key demand levers (positioning, adoption, competitive dynamics, lifecycle events)

Nice To Haves

Advanced degree preferred (e.g., MBA, MS, PhD in Statistics, Economics, Decision Sciences, Data Science, or related discipline).
Vaccines and/or Rare Disease experience, including familiarity with immunization dynamics, patient-based forecasting, and lifecycle management in preventive or immune-mediated therapies
Change leadership: builds adoption for new tools, processes, and ways of working across cross-functional stakeholders
Product mindset for forecasting: defines user needs, success metrics, and a roadmap for portfolio forecasting capabilities
Model lifecycle practices (e.g., reproducibility, versioning, monitoring/drift awareness); familiarity with MLOps concepts

Responsibilities

Lead US short-term and long-term demand forecasts (TRx, NBRx, volume, patients, revenue) for V&I assets using robust, patient-based and market-based models
Own forecast methodology, assumptions, and governance, ensuring objectivity, transparency, and consistency with enterprise standards
Integrate primary market research, epidemiology, competitive intelligence, access dynamics, and real-world data into forecast models
Proactively identify and quantify key risks and opportunities through scenario and sensitivity analyses
Partner closely with Finance, Market Access & Pricing, Marketing, Sales, Medical, and Global Forecasting to ensure alignment on assumptions and implications
Support business planning, governance reviews, and opportunity assessments with clear, executive-ready narratives
Serve as a trusted advisor to senior marketing and finance leadership, clearly articulating forecast drivers and changes
Provide leadership over forecasting-adjacent analytics, ensuring advanced analytics and insights are embedded into forecasting and business planning
Manage and prioritize internal analysts, contractors, and external vendors supporting forecasting and analytics deliverables
Partner with data analytics resources, Global IA&F, and GIBEX capability teams to deploy new tools, data sources, and modeling approaches
Champion and identify new ways to embed AI and advanced automation into the practice of data analytics and forecasting to drive efficiency, scalability, and decision quality
Champion continuous improvement in forecasting processes, AI-enabled modeling, and automation
Contribute to the development and sharing of best practices across the V&I forecasting community