Director, Translational Immunology

Travere Therapeutics • San Diego, CA

1d • $189,000 - $246,000 • Hybrid

About The Position

Travere Therapeutics is seeking an experienced and strategic scientist to join our Research and Nonclinical Development organization as Director, Translational Immunology. This individual will serve as a key scientific leader supporting an assigned development program primarily for rare-kidney disease and will play an important role in advancing translational and nonclinical strategies across current and future indications. The successful candidate will bring deep expertise in immunology and immune-mediated disease, including a strong understanding of B-cell biology combined with experience supporting clinical-stage drug development programs. Knowledge of kidney disease would be an advantage. This individual will work closely with Clinical Development, Clinical Pharmacology, Biometrics, Regulatory, Medical Affairs, and external collaborators to develop translational strategies, support nonclinical development activities, evaluate emerging scientific opportunities, and help identify additional indications where the asset may also provide meaningful therapeutic benefit. This role also represents an opportunity to contribute to the growth of immunology capabilities within a dynamic Research and Nonclinical Development organization and to assume increasing scientific leadership responsibilities as the organization expands.

Requirements

• Bachelor’s Degree in Life Science or other related discipline required.
• Minimum 10 years of relevant experience in the biopharmaceutical industry required; or 6 years with PhD, MD, PharmD, or equivalent.
• Demonstrated expertise in immunology, with strong knowledge of B-cell biology and immune signaling pathways.
• Experience supporting clinical-stage drug development programs.
• Experience translating mechanistic biology into development strategies and clinical applications.
• Experience leading externally conducted research through CROs, academic collaborators, and consultants.
• Working knowledge of regulatory requirements and expectations for nonclinical support of clinical development programs.
• Experience contributing to regulatory submissions, investigator brochures, briefing documents, or related development activities.
• Demonstrated ability to work effectively in cross-functional, matrixed organizations.
• Prior experience leading scientific initiatives, projects, or multidisciplinary teams.
• Excellent communication, presentation, and influencing skills.
• Scientific curiosity, intellectual rigor, and commitment to improving outcomes for patients with serious diseases.
• Ability to thrive in a collaborative, fast-paced, virtual biotechnology environment.

Nice To Haves

• PhD, MD, PharmD, or equivalent advanced degree in Immunology, Cell Biology, Molecular Biology, Pharmacology, or a related scientific discipline preferred.
• Equivalent combination of education and applicable job experience may be considered.
• Experience with immune signaling pathways.
• Experience with at least one or more of the following: autoimmune disease, inflammatory disease, rare disease, nephrology, or related therapeutic areas.
• Familiarity with at least one or more of the following: glomerular disease biology, proteinuric kidney diseases, podocytopathies, or mechanisms contributing to renal injury and disease progression.
• Experience supporting biomarker strategy and translational medicine initiatives.
• Experience evaluating disease mechanisms and identifying opportunities for therapeutic expansion into new indications.
• Experience serving as a scientific lead or key contributor on multidisciplinary development teams.
• Ability to integrate diverse scientific data sets to generate meaningful insights and guide decision-making.
• Strong project leadership and organizational skills.

Responsibilities

• Serve as the immunology lead supporting a late-stage clinical development program.
• Contribute to the development and execution of nonclinical and translational strategies aligned with program team objectives.
• Partner with cross-functional teams to support program governance, development planning, and scientific decision-making.
• Assess emerging scientific, clinical, and competitive developments relevant to assigned program and associated strategy.
• Contribute to the identification and evaluation of new therapeutic opportunities in rare disease for the assigned program that may provide clinical benefit.
• Develop translational strategies linking mechanism of action, target engagement, pharmacodynamic activity, and clinical outcomes.
• Support identification and implementation of mechanistic, pharmacodynamic, predictive, and response biomarkers.
• Collaborate with cross-functional teams to support implementation of biomarker strategies and data interpretation throughout development.
• Contribute to scientific publications, presentations, and external communications.
• Collaborate with Regulatory and nonclinical colleagues to support regulatory submissions and health authority interactions.
• Interpret pharmacology, toxicology, and translational data in the context of clinical development and regulatory objectives.
• Support preparation and review of investigator brochures, briefing documents, regulatory submissions, and other development-related documents.
• Ensure research and translational activities are aligned with development plans and regulatory expectations.
• Lead scientific interactions with CROs, academic collaborators, consultants, and key opinion leaders.
• Design, oversee, and contribute to interpretation of externally conducted translational and mechanistic nonclinical studies.
• Represent Travere at scientific meetings, conferences, and external collaborations.
• Identify and build productive scientific relationships that advance understanding of disease biology and therapeutic mechanisms.
• Contribute to building immunology and translational science capabilities within the Research and Nonclinical Development organization.
• Mentor colleagues and provide scientific leadership across programs and functions.
• Foster a culture of scientific excellence, collaboration, innovation, and continuous learning.
• Demonstrate the potential and desire to assume increasing scientific leadership responsibilities as the organization grows.
• Provide deep scientific expertise in B-cell biology, adaptive immunity, and innate immune signaling.
• Evaluate disease mechanisms and therapeutic opportunities in immune-mediated and rare diseases.
• Integrate mechanistic biology, translational science, and clinical observations to inform development strategies.
• Serve as an internal subject matter expert in immunology and immune-mediated disease biology.
• Maintain awareness of advances in disease biology, therapeutic targets, and emerging technologies relevant to immunology and translational medicine.

Benefits

• premium health, financial, work-life and well-being offerings for eligible employees and dependents
• wellness and employee support programs
• life insurance
• disability
• retirement plans with employer match
• generous paid time off

What This Job Offers

• Job Type: Full-time
• Career Level: Director