Director/Sr Director Pharmacometrics

Lilly • Indianapolis, IN

5d • Onsite

About The Position

At Eli Lilly and Company, our Global Pharmacokinetics/Pharmacodynamics and Pharmacometrics (PMx) team is dedicated to advancing the discovery and development of innovative medicines through interdisciplinary collaboration and the application of cutting-edge quantitative science and technology. Our vision is to be leaders in model-informed drug discovery, development, and decision-making, cultivating a community of exceptional scientists who transform insight into impact, improving global health. The PMx team operates across all phases of drug development and serves as a strategic scientific partner to project teams, regulatory functions, and senior leadership. We are currently investing in automation, AI/ML integration, and standardized modeling workflows to accelerate timelines and expand our impact. This role is designed for a scientist ready to operate as an enterprise-level scientific leader. The Director/Sr Director Pharmacometrics is expected to define which scientific problems matter (not just to solve them) and to shape PMx strategy across programs, platforms, and the broader organization. This is a high-visibility role with direct influence on drug development decisions, regulatory interactions, and team capability-building. You will serve as a trusted scientific partner whose input is actively sought by cross-functional leaders, PKPD colleagues, and senior partners. Your impact will extend well beyond the immediate project portfolio.

Requirements

• PhD in a relevant scientific field such as PMx, biological/pharmaceutical sciences, bioengineering, biostatistics, computer science/engineering, data science, or a related discipline. with 5 years post PhD experience
• Experience in population PKPD modeling, across multiple programs or development phases.
• Experince in NONMEM and/or Monolix, and R.

Nice To Haves

• Experience with mrgsolve, Julia, Phoenix NLME, and/or MATLAB is highly valued.
• Demonstrated ability to translate quantitative modeling outputs into clear scientific and regulatory narratives for cross-functional and non-specialist audiences.
• Proven track record of influencing drug development decisions and regulatory strategy through PMx analyses, with evidence of impact beyond a single project.
• MIDD Experience shaping technical strategy across programs or platforms, including involvement in regulatory submissions, health authority interactions, or cross-functional governance bodies.
• Strong mentorship and coaching skills, with experience developing the capabilities of more junior scientists.
• Active engagement with AI and automation in a PMx context, including hands-on experience with tools, a genuine curiosity for what's possible, and the judgment to translate innovation into practical scientific value. We are in the middle of a transformation, and this person will help lead it.
• Strong organizational and self-management skills, with the ability to manage a complex portfolio and prioritize for maximum scientific impact.

Responsibilities

• Champion MIDD approaches across programs and platforms, defining and delivering novel PMx strategies that shape drug development decisions.
• Resolve complex technical and scientific challenges with cross-program impact, contributing to exposure-response, dose justification, and regulatory submission strategies in collaboration with PKPD lead and across functions.
• Engage proactively with regulatory agencies through meetings, responses, and advisory interactions.
• Inspire and elevate the scientists around you through scientific leadership, mentorship, and good examples.
• Mentor scientists at all levels, building technical depth, scientific judgment, and confidence in others as a natural extension of how you work.
• Create the conditions for others to succeed: share knowledge generously, open doors, and actively invest in bench strength and organizational capability.
• Champion adoption of automation tools and AI/ML approaches that deliver pragmatic, scalable value across the department and beyond.
• Build PMx’s external reputation through publications and scientific leadership in industry and regulatory forums.
• Communicate complex science with executive presence to diverse audiences, from project teams to senior leadership.

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees